Right ventricular systolic dysfunction in young adults born preterm

Autor: Esther F. Davis, Stefan Neubauer, Kenny McCormick, Daniel Augustine, Paul Leeson, William M. Bradlow, Jane E. Francis, Adam J. Lewandowski, Atul Singhal, Alan Lucas
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Adult
Heart Defects
Congenital
Male
medicine.medical_specialty
Systole
Heart Ventricles
Ventricular Dysfunction
Right
Blood Pressure
Gestational Age
Infant
Premature
Diseases
Young Adult
Risk Factors
Physiology (medical)
Internal medicine
medicine
Birth Weight
Humans
Single-Blind Method
Prospective Studies
Young adult
Ventricular remodeling
Life Style
Randomized Controlled Trials as Topic
medicine.diagnostic_test
Anthropometry
Ventricular Remodeling
business.industry
Infant
Newborn
Gestational age
Reproducibility of Results
Magnetic resonance imaging
Stroke Volume
Organ Size
medicine.disease
Magnetic Resonance Imaging
Right ventricular systolic dysfunction
medicine.anatomical_structure
Premature birth
Ventricle
Cardiology
End-diastolic volume
Female
Cardiology and Cardiovascular Medicine
business
Infant
Premature
Follow-Up Studies
Popis: Background— Young adults born preterm have distinct differences in left ventricular mass, function, and geometry. Animal studies suggest that cardiomyocyte changes are evident in both ventricles after preterm birth; therefore, we investigated whether these young adults also have differences in their right ventricular structure and function. Methods and Results— We studied 102 preterm-born young adults followed up prospectively since birth and 132 term-born control subjects born to uncomplicated pregnancies. We quantified right ventricular structure and function by cardiovascular magnetic resonance on a 1.5-T Siemens scanner using Argus and TomTec postprocessing software. Preterm birth was associated with a small right ventricle (end diastolic volume, 79.8±13.2 versus 88.5±11.8 mL/m 2 ; P 2 ; P r =−0.47, P P =0.006). Indeed, 21% had values below the lower limit observed in the term-born adults and 6% had mild systolic dysfunction ( Conclusions— Preterm birth is associated with global myocardial structural and functional differences in adult life, including smaller right ventricular size and greater mass. The changes are greater in the right ventricle than previously observed in the left ventricle, with potentially clinically significant impairment in right ventricular systolic function.
Databáze: OpenAIRE
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