Impact of Perioperative Chemotherapy on Prognosis of Patients with Esophageal Carcinoma Undergoing Pulmonary Metastasectomy

Autor: Hidetoshi Inoue, Hiroaki Komatsu, Takuma Tsukioka, Hikaru Miyamoto, Nobuhiro Izumi, Noritoshi Nishiyama
Rok vydání: 2019
Předmět:
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Lung Neoplasms
Time Factors
Esophageal Neoplasms
medicine.medical_treatment
030204 cardiovascular system & hematology
Drug Administration Schedule
esophageal carcinoma
03 medical and health sciences
0302 clinical medicine
Blood loss
Risk Factors
Perioperative chemotherapy
Antineoplastic Combined Chemotherapy Protocols
Carcinoma
medicine
Humans
Pneumonectomy
pulmonary metastasis
Survival rate
Aged
Retrospective Studies
business.industry
Metastasectomy
Gastroenterology
prognostic factors
General Medicine
Perioperative
Middle Aged
medicine.disease
Progression-Free Survival
Surgery
Esophagectomy
030228 respiratory system
Chemotherapy
Adjuvant
perioperative chemotherapy
Female
Original Article
Fluorouracil
Cisplatin
Cardiology and Cardiovascular Medicine
business
Wedge resection (lung)
Zdroj: Annals of Thoracic and Cardiovascular Surgery
ISSN: 2186-1005
1341-1098
Popis: Purpose: To evaluate prognosis of patients with esophageal carcinoma undergoing pulmonary metastasectomy, and help determine appropriate therapeutic strategies. Methods: We retrospectively studied 16 patients (15 men and one woman; median age 66.5 years) with esophageal carcinoma, who underwent curative resection of pulmonary metastases. Clinical characteristics and surgical outcomes were analyzed. Results: In all, 11 patients underwent wedge resection, three segmentectomy, and two lobectomies. The average operating time and blood loss were 147 min and 103 mL, respectively. There were no perioperative deaths or severe complications. Five-year overall survival rate was 40.2% and 2-year disease-free survival rate was 35.2%. All recurrences occurred within 2 years. Univariate and multivariate analyses revealed that absence of adjuvant chemotherapy after therapy for esophageal carcinoma was a significant predictor of poor prognosis and recurrence, respectively (p
Databáze: OpenAIRE
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