Emerging role of signal transducer and activator of transcription 3 (STAT3) in pituitary adenomas
| Autor: | Toru Tateno, Tae Nakano-Tateno, Constance L. Chik, Motoyasu Satou, Cyndy Liu |
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| Rok vydání: | 2021 |
| Předmět: |
Adenoma
STAT3 Transcription Factor biology business.industry Cell growth Endocrinology Diabetes and Metabolism Gene Expression medicine.disease_cause Endocrinology Gene expression biology.protein Null cell Cancer research STAT protein Animals Humans Medicine Pituitary Neoplasms Secretion business STAT3 Carcinogenesis Transcription factor |
| Zdroj: | Endocrine Journal. 68:1143-1153 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.ej21-0106 |
| Popis: | Pituitary adenomas are benign tumours that can cause an individual various clinical manifestations including tumour mass effects and/or the diverse effects of abnormal pituitary hormone secretion. Given the morbidity and limited treatment options for pituitary adenomas, there is a need for better biomarkers and treatment options. One molecule that is of specific interest is the signal transducer and activator of transcription 3 (STAT3), a transcription factor that plays a critical role in mediating cytokine-induced changes in gene expression. In addition, STAT3 controls cell proliferation by regulating mitochondrial activity. Not only does activation of STAT3 play a crucial role in tumorigenesis, including pituitary tumorigenesis, but a number of studies also demonstrate pharmacological STAT3 inhibition as a promising treatment approach for many types of tumours, including pituitary tumours. This review will focus on the role of STAT3 in different pituitary adenomas, in particular, growth hormone-producing adenomas and null cell adenomas. Furthermore, how STAT3 is involved in the cell proliferation and hormone regulation in pituitary adenomas and its potential role as a molecular therapeutic target in pituitary adenomas will be summarized. |
| Databáze: | OpenAIRE |
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