MRI of Cardiac Sarcoidosis: Basal and Subepicardial Localization of Myocardial Lesions and Their Effect on Left Ventricular Function
| Autor: | Shoki Takahashi, Minako Oikawa, Kei Takase, Hiroki Otani, Azusa Ichinose, Haruo Saito, Hiroaki Shimokawa |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Cardiac function curve Systemic disease Sarcoidosis medicine.drug_class Sensitivity and Specificity Lesion Ventricular Dysfunction Left Image Interpretation Computer-Assisted Natriuretic Peptide Brain medicine Natriuretic peptide Humans Radiology Nuclear Medicine and imaging Myocardial infarction business.industry Reproducibility of Results General Medicine Middle Aged medicine.disease Brain natriuretic peptide Magnetic Resonance Imaging medicine.anatomical_structure Ventricle cardiovascular system Female medicine.symptom Cardiomyopathies business Nuclear medicine |
| Zdroj: | American Journal of Roentgenology. 191:862-869 |
| ISSN: | 1546-3141 0361-803X |
| Popis: | The objective of our study was to use MRI to analyze the topographic localization of myocardial lesions and their relationship to plasma brain natriuretic peptide (BNP) levels and several cardiac function parameters in patients with cardiac sarcoidosis.Delayed contrast-enhanced MRI was performed in 40 patients with sarcoidosis (11 cardiac, 29 extracardiac cases). Using a 29-segment model of the left ventricle (LV), the extent of myocardial hyperenhancement was visually scored (0 = no hyperenhancement, 1 = 1-25%, 2 = 26-50%, 3 = 51-75%, 4 = 76-100% hyperenhancement) and was compared with plasma BNP level and several parameters of cardiac function.Ten of the 11 patients with cardiac sarcoidosis showed myocardial hyperenhancement, whereas none of the 29 patients without cardiac sarcoidosis did. In patients with cardiac sarcoidosis, hyperenhancement was significantly more extensive in basal short axis slices than in apical short axis slices (p0.0005). Myocardial hyperenhancement was significantly more frequent in subepicardial layers than in subendocardial layers. The global extent of myocardial hyperenhancement was significantly correlated with plasma BNP levels and the LV end-diastolic volume index and was negatively correlated with the LV ejection fraction.In patients with cardiac sarcoidosis, myocardial lesions detected on delayed contrast-enhanced MRI were predominantly localized in the basal and subepicardial myocardium. The extent of myocardial lesions may be related to LV dysfunction and plasma BNP level in patients with cardiac sarcoidosis. |
| Databáze: | OpenAIRE |
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