Tumor-Specific Activatable Nanocarriers with Gas-Generation and Signal Amplification Capabilities for Tumor Theranostics
| Autor: | Chao Qi, Jing Lin, Ting He, Peng Huang, Lian-Hua Fu, Jin He, Xikuang Yao, Nicholas Thomas Blum |
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| Rok vydání: | 2020 |
| Předmět: |
General Physics and Astronomy
Nanoparticle Antineoplastic Agents 02 engineering and technology 010402 general chemistry 01 natural sciences Theranostic Nanomedicine In vivo Neoplasms medicine Tumor Microenvironment Humans General Materials Science Doxorubicin Precision Medicine Tumor microenvironment Chemistry General Engineering 021001 nanoscience & nanotechnology In vitro 0104 chemical sciences Ultrasound imaging Biophysics Nanoparticles Nanocarriers 0210 nano-technology Signal amplification medicine.drug |
| Zdroj: | ACS nano. 15(1) |
| ISSN: | 1936-086X |
| Popis: | Multifunctional nanotheranostics are typically designed by integrating multiple functional components. This approach not only complicates the preparation process but also hinders any bioapplication due to the potential toxic effects when each component is metabolized. Here, we report a safe, biodegradable, and tumor-specific nanocarrier that, once activated by the acidic tumor microenvironment (TME), has diagnostic and therapeutic functions suitable for tumor theranostics. Our nanocarrier is composed of biomineralized manganese carbonate (BMC) nanoparticles (NPs) that readily decompose to release Mn2+ ions and CO2 gas in the acidic TME due to its intrinsic pH-dependent solubility. Mn2+ and CO2 release permits magnetic resonance and ultrasound imaging of tumors, respectively. These NPs can be loaded with the anticancer drug doxorubicin (DOX): BMC-DOX has high tumor inhibition effects both in vitro and in vivo due to combined Mn2+-mediated chemodynamic therapy and DOX-induced chemotherapy. This tumor-specific actuating nanocarrier might be a promising candidate for clinical translation. |
| Databáze: | OpenAIRE |
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