Fast laser-induced solute release from liposomes sensitized with photochromic lipid: effects of temperature, lipid host, and sensitizer concentration
| Autor: | Roger H. Bisby, Christopher G. Morgan, Andrew C. Mitchell, Carole Mead |
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| Rok vydání: | 1999 |
| Předmět: |
Periodicity
Ultraviolet Rays Kinetics Lipid Bilayers Biophysics Phospholipid Biochemistry Permeability law.invention Photochromism chemistry.chemical_compound Drug Delivery Systems law Lipid bilayer Molecular Biology Liposome Chromatography Photolysis Photosensitizing Agents Chemistry Lasers Pulsed laser irradiation Temperature Dose-Response Relationship Radiation Cell Biology Laser Fluoresceins Drug delivery Liposomes Phosphatidylcholines |
| Zdroj: | Biochemical and biophysical research communications. 262(2) |
| ISSN: | 0006-291X |
| Popis: | Liposomes of gel-phase phospholipid have been prepared containing a photochromic lipid sensitizer. A fast UV laser pulse isomerizes the sensitizer destabilizing the lipid bilayer structure and causing release of trapped solute. The kinetics of solute release have been investigated as a function of host lipid chain length, sensitizer concentration, and temperature, and the limits of liposome stability have been established. At low concentrations of sensitizer, pulsed laser irradiation induces some solute release when continuous UV illumination is ineffective. Although rates of solute release usually increase with temperature, at low sensitizer concentration in a rigid host, leakage at first increases but then decreases rapidly above a threshold temperature. The results presented are relevant to the design of photostimulated drug delivery systems and to potential applications of photosensitive liposomes as caging agents for biological effectors. |
| Databáze: | OpenAIRE |
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