Post-transcriptional regulation of gene expression in innate immunity
Autor: | Blandine C. Mercier, Katherine A. Fitzgerald, Susan Carpenter, Emiliano P. Ricci, Melissa J. Moore |
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Rok vydání: | 2014 |
Předmět: |
History
RNA Untranslated RNA Stability Inflammation Adaptive Immunity Biology Polyadenylation Education Mice MRNA polyadenylation Immunity Gene expression medicine Transcriptional regulation Animals Humans RNA Messenger RNA Processing Post-Transcriptional Post-transcriptional regulation Innate immune system Toll-Like Receptors Dendritic Cells Acquired immune system Immunity Innate Computer Science Applications Cell biology Alternative Splicing Gene Expression Regulation Protein Biosynthesis Immunology medicine.symptom Signal Transduction |
Zdroj: | Nature Reviews Immunology. 14:361-376 |
ISSN: | 1474-1741 1474-1733 |
DOI: | 10.1038/nri3682 |
Popis: | Innate immune responses combat infectious microorganisms by inducing inflammatory responses, antimicrobial pathways and adaptive immunity. Multiple genes within each of these functional categories are coordinately and temporally regulated in response to distinct external stimuli. The substantial potential of these responses to drive pathological inflammation and tissue damage highlights the need for rigorous control of these responses. Although transcriptional control of inflammatory gene expression has been studied extensively, the importance of post-transcriptional regulation of these processes is less well defined. In this Review, we discuss the regulatory mechanisms that occur at the level of mRNA splicing, mRNA polyadenylation, mRNA stability and protein translation, and that have instrumental roles in controlling both the magnitude and duration of the inflammatory response. |
Databáze: | OpenAIRE |
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