Dietary polyphenols promote resilience against sleep deprivation‐induced cognitive impairment by activating protein translation
| Autor: | Tal Frolinger, Jing Huang, Giulio Maria Pasinetti, Justin Brathwaite, Steven Sims, Carmen Freire Cobo, Chad Smith, Sterre de Boer |
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| Přispěvatelé: | VU University medical center |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell Cycle Proteins mTORC1 Pharmacology Hippocampus Biochemistry Dietary Polyphenol Mice 03 medical and health sciences 0302 clinical medicine Genetics medicine Animals Cognitive Dysfunction Eukaryotic Initiation Factors Molecular Biology PI3K/AKT/mTOR pathway Adaptor Proteins Signal Transducing Neurons Kinase Chemistry Research EIF4E Polyphenols Ribosomal Protein S6 Kinases 70-kDa Phosphoproteins Disease Models Animal Sleep deprivation Eukaryotic Initiation Factor-4E 030104 developmental biology Protein Biosynthesis Ribosomal protein s6 Sleep Deprivation Phosphorylation medicine.symptom Carrier Proteins 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Frolinger, T, Smith, C, Cobo, C F, Sims, S, Brathwaite, J, de Boer, S, Huang, J & Pasinetti, G M 2018, ' Dietary polyphenols promote resilience against sleep deprivation-induced cognitive impairment by activating protein translation ', FASEB Journal, vol. 32, no. 10, pp. 539-5404 . https://doi.org/10.1096/fj.201800030R FASEB Journal, 32(10), 539-5404. FASEB |
| ISSN: | 1530-6860 0892-6638 |
| Popis: | Previous evidence has suggested that dietary supplementation with a bioactive dietary polyphenol preparation (BDPP) rescues impairment of hippocampus-dependent memory in a mouse model of sleep deprivation (SD). In the current study, we extend our previous evidence and demonstrate that a mechanism by which dietary BDPP protects against SD-mediated cognitive impairment is via mechanisms that involve phosphorylation of the mammalian target of rapamycin complex 1 and its direct downstream targets, including the eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) and the ribosomal protein S6 kinase β-1 (p70S6K). In additional mechanistic studies in vitro, we identified the brain bioavailable phenolic metabolites derived from the metabolism of dietary BDPP that are responsible for the attenuation of SD-mediated memory impairments. On the basis of high-throughput bioavailability studies of brain bioavailable metabolites after dietary BDPP treatment, we found that select polyphenol metabolites [ e.g., cyanidin-3'- O-glucoside and 3-(3'-hydroxyphenyl) propionic acid] were able to rescue mTOR and p70S6K phosphorylation in primary cortico-hippocampal neuronal cultures, as well as rescue 4E-BP1 phosphorylation in response to treatment with 4EGI-1, a specific inhibitor of eIF4E-eIF4G interaction. Our findings reveal a previously unknown role for dietary polyphenols in the rescue of SD-mediated memory impairments via mechanisms involving the promotion of protein translation.-Frolinger, T., Smith, C., Cobo, C. F., Sims, S., Brathwaite, J., de Boer, S., Huang, J., Pasinetti, G. M. Dietary polyphenols promote resilience against sleep deprivation-induced cognitive impairment by activating protein translation. |
| Databáze: | OpenAIRE |
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