A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules
| Autor: | Michael Odoi Kyene, Doris Kumadoh, Alfred Ampomah Appiah, Susana Oteng Mintah, Emmanuel Adase, Mary-Ann Archer, Christina Osei-Asare, Mavis Boakye-Yiadom, Ofosua Adi-Dako, Genevieve Naana Yeboah |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
H1-99
Multidisciplinary Science (General) biology Traditional medicine Helicobacter pylori business.industry Peptic ulcer disease Herbal therapy biology.organism_classification medicine.disease digestive system diseases Social sciences (General) Q1-390 Peptic ulcer Anti-ulcer activity Medicine Electronic data Dyspepsia Medicinal plants business Herbal products Enterica |
| Zdroj: | Heliyon, Vol 7, Iss 12, Pp e08465-(2021) |
| ISSN: | 2405-8440 |
| Popis: | Peptic ulcer disease affects many people globally. With the increasing resistance to some orthodox antibiotics such as Clarithromycin and Metronidazole, it is important that new acceptable, safer and effective therapies are developed to manage this disease. Various herbal medicines have been used traditionally for the remedy of peptic ulcer disease (PUD), however scientific information with regards to their anti-peptic ulcer both in-vivo and in-vitro as well as clinical studies supporting their use is still inadequate. The Centre for Plant Medicine Research, (CPMR) Mampong-Akuapem, Ghana manufactures three herbal Products namely Enterica, Dyspepsia and NPK 500 capsules which are currently used for the remedy of PUD as a triple therapy at its out-patient clinic with promising effects. The aim of this review is to gather information from literature on the anti-ulcer properties, pharmacological, phytochemical constituents and related activities of herbal plants used at the CPMR for formulation of the triple herbal therapy. This review may, provide some scientific bases for the use of Enterica, Dyspepsia and NPK 500 capsules in the management of Peptic ulcer at the CPMR out-patient clinic. Methods Organization for the review involved the on and/or offline search for information from available literature using electronic data and scientific research information resources such as PubMed, Science Direct and Google scholar. Results In this review, fifteen ethno-medicinal plants used for the formulation of Enterica, Dyspepsia and NPK capsules have been discussed, presenting the description of the plants, composition and pharmacological activity. Interpretation Tables with the summary of reviewed medicinal plants with their anti-ulcer models and inference on possible mechanisms of action were drawn up. The mechanism(s) of action of individual plants and products (Enterica, Dyspepsia and NPK 500 capsules) must be further investigated and established experimentally in-vitro in addition to in-vivo pharmacological and clinical activity studies to confirm their use in the remedy of PUD. |
| Databáze: | OpenAIRE |
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