Structural and metabolic changes characterizing the aging of various cartilages in mice
| Autor: | Erella Livne, A. Weiss, Jack Bernheim, Michael Silbermann |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
Aging medicine.medical_specialty Male mice Biology Mice Internal medicine medicine Animals Intervertebral Disc Hyaline Mice Inbred ICR Sulfates Cartilage Body Weight Mandibular Condyle DNA Organ Size Metabolism Skeleton (computer programming) Endocrinology medicine.anatomical_structure Ageing Ultrastructure Xiphoid Bone Leucine Developmental Biology |
| Zdroj: | Mechanisms of Ageing and Development. 35:145-160 |
| ISSN: | 0047-6374 |
| DOI: | 10.1016/0047-6374(86)90005-9 |
| Popis: | It is well documented that various organs and tissues in the body show a differential, non-homogenous pattern of development and aging. The present study evaluates some of the morphological and metabolic changes characterizing the aging of different types of cartilages in normal male mice. Representatives of hyaline, fibrous, articular and elastic types of cartilage were obtained from animals ranging from 1 week to 1 year of age. Our determinations included the following: total body and organ weights, proteins and DNA concentration, [ 3 H]leucine and [ 35 S]sulfate uptake. The biochemical assays were accompanied by morphological examinations of corresponding tissue specimens. This investigation clearly indicates that the growth and maturational activities of the various cartilages examined attained their completion at a very early stage of life (1–3 months postnatally). Thereafter, a phase of steady state prevails, followed by a gradual but continuous decline in the various metabolic activities. The morphological findings illustrate the nature of the age-related structural changes. The present findings indicate that a skeletal tissue such as cartilages of various types, tends to age early during the lifespan of the animal. |
| Databáze: | OpenAIRE |
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