Effect of aging on the distribution of basic fibroblast growth factor immunoreactive cells in the rat hippocampus
| Autor: | Emsal Salik, Feriha Ercan, Tangül Şan, Serap Sirvanci, Şule Çetinel, Filiz Onat |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Aging Neurite Basic fibroblast growth factor Hippocampus Cell Count Stimulation Hippocampal formation Biology chemistry.chemical_compound Animals Distribution (pharmacology) Rats Wistar Analysis of Variance General Neuroscience Age Factors Immunohistochemistry In vitro Rats Cell biology nervous system chemistry Astrocytes cardiovascular system Fibroblast Growth Factor 2 Neuroscience |
| Zdroj: | Brain Research Bulletin. 64:409-415 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/j.brainresbull.2004.09.010 |
| Popis: | Hippocampal formation is extremely sensitive to the aging process and appears to be one of the first regions to show structural and physiological changes with advancing age. Basic fibroblast growth factor (bFGF) plays an important role in the stimulation of mitogenesis in glial cells, the support of neuronal survival and the promotion of neurite outgrowth in vitro. In the present study, the effect of aging on the distribution of bFGF immunoreactive (bFGF-ir) cells was investigated. The protein product of bFGF was visualized immunohistochemically in the dorsal hippocampus of Wistar albino rats. bFGF-ir astrocytes in different subfields of hippocampus and neurons in CA2 field were quantified to determine whether changes in immunoreactivity were correlated with advancing age. Aging was accompanied by a decrease in bFGF-ir cell density in subfields of hippocampus. We concluded that aging was associated with a reduction in bFGF-ir cell density that may reflect a decreased expression of bFGF in the rat hippocampus. |
| Databáze: | OpenAIRE |
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