Postbinding insulin resistance around parturition in the isolated rat epitrochlearis muscle
| Autor: | Nagayasu Toyoda, T. Yamamoto, Tsukio Deguchi, Yoichi Sugiyama, Kazuhira Murata |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Blood Glucose
medicine.medical_specialty medicine.medical_treatment In Vitro Techniques Insulin resistance Adenosine Triphosphate Pregnancy Internal medicine Lactation medicine Animals Insulin Pancreatic hormone Labor Obstetric biology business.industry Muscles Postpartum Period Skeletal muscle Obstetrics and Gynecology Biological Transport Rats Inbred Strains medicine.disease Rats Insulin receptor Endocrinology medicine.anatomical_structure biology.protein Pregnancy Animal Female business Postpartum period |
| Zdroj: | American Journal of Obstetrics and Gynecology. 165:1475-1480 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/s0002-9378(12)90788-7 |
| Popis: | To determine whether insulin resistance exists in maternal skeletal muscle during pregnancy and how it returns to normal during the postpartum period, 3-0-methyl[ 14 C]-d-glucose transport and [ 125 I]insulin-binding activities were measured in isolated rat epitrochlearis muscle. Maximally insulin-stimulated methylglucose transport activity was decreased on day 20 of pregnancy and on days 1 and 4 post partum; it returned to the nonpregnant level by day 9. The insulin-binding activity did not change significantly throughout pregnancy, increased on days 1 and 4 post partum, and returned to the nonpregnant level by day 9. There was no significant difference in insulin binding or insulin-stimulated methylglucose transport activity between lactating and nonlactating animals. These results suggest that insulin resistance caused by postbinding changes in epitrochlearis muscle develops during late pregnancy and continues at least until day 4 post partum. Lactation does not appear to have a significant effect on insulin resistance. |
| Databáze: | OpenAIRE |
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