Heart disease in Friedreich's ataxia: observation of a case for half a century
| Autor: | Hideyuki Haebara, Hisayoshi Fujiwara, Shotaro Kato, Chuichi Kawai, Masayuki Takashima |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Ataxia Heart disease Heart Diseases Physiology Autopsy QT interval Central nervous system disease Electrocardiography Internal medicine medicine Humans Aged medicine.diagnostic_test business.industry Hypertrophic cardiomyopathy Middle Aged medicine.disease Surgery Natural history Friedreich Ataxia cardiovascular system Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Japanese circulation journal. 64(3) |
| ISSN: | 0047-1828 |
| Popis: | A case of Friedreich's ataxia was followed for 47 years, beginning in 1930; this patient had an abnormal electrocardiogram (flat or inverted T waves in leads II and III with prolonged QT interval) from the very beginning of the onset of neurological symptoms. Cardiac and neurological disturbances progressed slowly but steadily, and the patient died suddenly at the age of 67. The autopsy revealed typical findings of Friedreich's ataxia and hypertrophic cardiomyopathy with thickened left ventricular wall and myocardial fiber disarray. To the authors' knowledge, this is the longest continuous follow-up study of Friedreich's ataxia, and it will provide invaluable information on the natural history and development of the cardiac and neurological disorders in this condition. |
| Databáze: | OpenAIRE |
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