EFFECTS OF SACUBITRIL/VALSARTAN ON THE ARTERIAL STIFFNESS AND LEFT VENTRICULAR-ARTERIAL COUPLING IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
| Autor: | I. Meray, O. I. Lukina, Zh. D. Kobalava, Е. E. Shkolnikova, Svetlana Villevalde |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
RM1-950 Sacubitril Internal medicine medicine Diseases of the circulatory (Cardiovascular) system Pharmacology (medical) heart failure with reduced ejection fraction Myocardial infarction Ejection fraction business.industry left ventricular-arterial coupling medicine.disease Blood pressure arterial stiffness Valsartan Heart failure sacubitril/valsartan RC666-701 Arterial stiffness Cardiology Therapeutics. Pharmacology Cardiology and Cardiovascular Medicine business Sacubitril Valsartan medicine.drug |
| Zdroj: | Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 14, Iss 2, Pp 210-216 (2018) |
| ISSN: | 2225-3653 1819-6446 |
| Popis: | Aim. To study the effects of sacubitril/valsartan on left ventricular-arterial coupling (LVAC) and arterial stiffness in HFrEF patients.Material and methods. Arterial stiffness by applanation tonometry and LVAC – by two-dimensional echocardiography were evaluated in 18 patients with compensated HFrEF (age 69Ѓ}9 years, 89% male, arterial hypertension – 83%, diabetes – 39%, myocardial infarction – 89%, left ventricular ejection fraction 32Ѓ}4%) initially and after 6 and 12 months of therapy based on sacubitril/valsartan. LVAC was calculated as the Ea (arterial elastance)/ Ees (left ventricular elastance) ratio. Differences were considered statistically significant at p10 m/s). The decrease in PWV (from 11.5Ѓ}2.9 to 10.2Ѓ}2.9 m/s, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|