Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R)

Autor:	Daria Darczak, Rachel Davis-Taber, Michael F. Jarvis, Victoria E. Scott, Marie E. Uchic, Xenia Beebe, Andrew O. Stewart
Rok vydání:	2008
Předmět:	Magnetic Resonance Spectroscopy endocrine system diseases Stereochemistry education Clinical Biochemistry Pharmaceutical Science Adenylate kinase Receptor type Hydrazide Biochemistry Cyclase Radioligand Assay Structure-Activity Relationship chemistry.chemical_compound health services administration Drug Discovery Humans Molecular Biology Cells Cultured Peptide ligand G protein-coupled receptor Molecular Structure Organic Chemistry food and beverages Small molecule humanities Hydrazines chemistry Pituitary Adenylate Cyclase-Activating Polypeptide Molecular Medicine Calcium Receptors Pituitary Adenylate Cyclase-Activating Polypeptide Type I
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 18:2162-2166
ISSN:	0960-894X
Popis:	Potent small molecule antagonists for the PAC(1)-R have been discovered. Previously known antagonists for the PAC(1)-R were slightly truncated peptide ligands. The hydrazides reported here are the first small molecule antagonists ever reported for this class B GPCR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be63d4ff1b7d10cefce0b81ec2275556 https://doi.org/10.1016/j.bmcl.2008.01.052 Zobrazit plný text záznamu Full Text from ScienceDirect