Kinase detection with gallium nitride based high electron mobility transistors
| Autor: | Ramon Collazo, Jinqiao Xie, Consuelo Arellano, Isaac Bryan, Albena Ivanisevic, Zlatko Sitar, Matthew S. Makowski |
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| Rok vydání: | 2013 |
| Předmět: |
Materials science
Physics and Astronomy (miscellaneous) Transistor Wide-bandgap semiconductor Nanoparticle Nanotechnology Gallium nitride High-electron-mobility transistor law.invention chemistry.chemical_compound chemistry law Colloidal gold Biophysics and Bio-Inspired Systems Biosensor Proto-oncogene tyrosine-protein kinase Src |
| Zdroj: | Applied Physics Letters. 103:013701 |
| ISSN: | 1077-3118 0003-6951 |
| DOI: | 10.1063/1.4812987 |
| Popis: | A label-free kinase detection system was fabricated by the adsorption of gold nanoparticles functionalized with kinase inhibitor onto AlGaN/GaN high electron mobility transistors (HEMTs). The HEMTs were operated near threshold voltage due to the greatest sensitivity in this operational region. The Au NP/HEMT biosensor system electrically detected 1 pM SRC kinase in ionic solutions. These results are pertinent to drug development applications associated with kinase sensing. |
| Databáze: | OpenAIRE |
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