| Autor: |
Mojca Jensterle, Simona Ferjan, Luka Ležaič, Aljaž Sočan, Katja Goričar, Katja Zaletel, Andrej Janez |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Diabetes, obesity and metabolism, vol. 25, no. 4, pp. 975-984, 2023. |
| ISSN: |
1462-8902 |
| Popis: |
Aim: To evaluate the effect of once-weekly subcutaneous semaglutide 1.0 mg on the late digestive period of gastric emptying (GE) after ingestion of a standardized solid test meal by using technetium scintigraphy, the reference method for this purpose. Methods: We conducted a single-blind, placebo-controlled trial in 20 obese women with polycystic ovary syndrome (PCOS mean [range] age 35 [32.3-40.8] years, body mass index 37 [30.7-39.8] kg/m$^2$) randomized to subcutaneous semaglutide 1.0 mg once weekly or placebo for 12 weeks. GE was assessed after ingestion of [$^{99mT}$c] colloid in a pancake labelled with radiopharmaceutical by scintigraphy using sequential static imaging and dynamic acquisition at baseline and at Week 13. Estimation of GE was obtained by repeated imaging of remaining [$^{99mT}$c] activity at fixed time intervals over the course of 4 hours after ingestion. Results: From baseline to the study end, semaglutide increased the estimated retention of gastric contents by 3.5% at 1 hour, 25.5% at 2 hours, 38.0% at 3 hours and 30.0% at 4 hours after ingestion of the radioactively labelled solid meal. Four hours after ingestion, semaglutide retained 37% of solid meal in the stomach compared to no gastric retention in the placebo group (P = 0.002). Time taken for half the radiolabelled meal to empty from the stomach was significantly longer in the semaglutide group than the placebo group (171 vs. 118 min P < 0.001). Conclusion: Semaglutide markedly delayed 4-hour GE in women with PCOS and obesity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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