Interleukin 6, galectin 3, growth differentiation factor 15, and soluble ST2 for mortality prediction in critically ill patients
| Autor: | Margot Egger, Fritz Firlinger, Werner Poelz, Kurt Lenz, Meinhard Haltmayer, Isabella Leitner, Benjamin Dieplinger, Thomas Mueller |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Growth Differentiation Factor 15 Critical Care Critical Illness Galectin 3 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Procalcitonin Cohort Studies 03 medical and health sciences 0302 clinical medicine Interleukin 33 Predictive Value of Tests Internal medicine Transforming growth factor super family Medicine Humans Simplified Acute Physiology Score Intensive care medicine Interleukin 6 Aged Univariate analysis biology business.industry Interleukin-6 030208 emergency & critical care medicine Middle Aged Prognosis Troponin Interleukin-1 Receptor-Like 1 Protein Hospitalization Interleukin 1 receptor family Intensive Care Units SAPS II Austria Cohort biology.protein Female GDF15 business Biomarkers Natriuretic peptide |
| Zdroj: | Journal of critical care. 34 |
| ISSN: | 1557-8615 |
| Popis: | Purpose The aim of this study was to compare the prognostic value of interleukin 6 (IL-6), galectin 3, growth differentiation factor 15 (GDF-15), and soluble ST2 (sST2) in an unselected cohort of critically ill patients. Methods During a study period of 1 year, we recruited 530 consecutive patients admitted to a medical intensive care unit of a tertiary care hospital. We examined a combination of inflammatory, renal, and cardiac biomarkers for the prediction of 90-day all-cause mortality. Results During follow-up, 118 patients died (22%). In univariate analyses, increased IL-6, galectin 3, GDF-15, and sST2 plasma concentrations at baseline were strong prognostic markers. However, in the multivariate models, only IL-6 and sST2 remained independent biomarkers adding additional prognostic information to the routinely used Simplified Acute Physiology Score (SAPS) II. Using a simple multimarker approach, patients with increased SAPS II, IL-6, and sST2 (ie, SAPS II > 35, IL-6 > 32.3 pg/mL, and sST2 > 103 ng/mL) had the poorest outcome. Conclusions In this heterogeneous group of critically ill patients, only SAPS II, IL-6, and sST2 remained independent and additive prognostic markers for 90-day all-cause mortality. A combination of the SAPS II with the 2 complementary biomarkers might provide a valuable tool for risk stratification of critically ill patients. |
| Databáze: | OpenAIRE |
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