Role and regulation of MKP-1 in airway inflammation
| Autor: | Alaina J. Ammit, Seyed M. Moosavi, Pavan Prabhala |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
P38 MAPK
0301 basic medicine MAPK/ERK pathway SMOOTH-MUSCLE-CELLS Respiratory System Anti-Inflammatory Agents Context (language use) Inflammation Protein tyrosine phosphatase Review OBSTRUCTIVE PULMONARY-DISEASE 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Dual-specificity phosphatase medicine Animals Humans Protein kinase A IMMEDIATE-EARLY GENE lcsh:RC705-779 biology Effector ACTIVATED PROTEIN-KINASE Dual Specificity Phosphatase 1 IN-VITRO lcsh:Diseases of the respiratory system TYROSINE-PHOSPHATASE MAP KINASE Respiration Disorders BETA(2)-ADRENOCEPTOR AGONISTS ENHANCE 030104 developmental biology 030220 oncology & carcinogenesis Immunology biology.protein DUAL-SPECIFICITY PHOSPHATASE medicine.symptom Inflammation Mediators |
| Zdroj: | Respiratory Research Respiratory Research, Vol 18, Iss 1, Pp 1-12 (2017) |
| ISSN: | 1465-993X 1465-9921 |
| Popis: | Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a protein with anti-inflammatory properties and the archetypal member of the dual-specificity phosphatases (DUSPs) family that have emerged over the past decade as playing an instrumental role in the regulation of airway inflammation. Not only does MKP-1 serve a critical role as a negative feedback effector, controlling the extent and duration of pro-inflammatory MAPK signalling in airway cells, upregulation of this endogenous phosphatase has also emerged as being one of the key cellular mechanism responsible for the beneficial actions of clinically-used respiratory medicines, including β2-agonists, phosphodiesterase inhibitors and corticosteroids. Herein, we review the role and regulation of MKP-1 in the context of airway inflammation. We initially outline the structure and biochemistry of MKP-1 and summarise the multi-layered molecular mechanisms responsible for MKP-1 production more generally. We then focus in on some of the key in vitro studies in cell types relevant to airway disease that explain how MKP-1 can be regulated in airway inflammation at the transcriptional, post-translation and post-translational level. And finally, we address some of the potential challenges with MKP-1 upregulation that need to be explored further to fully exploit the potential of MKP-1 to repress airway inflammation in chronic respiratory disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|