Genetic polymorphism analysis of MICB gene in Jing ethnic minority of Southern China

Autor:	Limin Liu, Yuming Meng, Shengming Dai, Xiaomou Wei, Xiang Chen, Xuexiang Liu
Rok vydání:	2018
Předmět:	Untranslated region China Linkage disequilibrium Genotype Immunology Population Biology Linkage Disequilibrium Exon Gene Frequency Ethnicity Genetics Humans Immunology and Allergy Coding region Promoter Regions Genetic education Gene Minority Groups education.field_of_study Polymorphism Genetic Histocompatibility Antigens Class I Haplotype Transplantation Genetics Population Haplotypes
Zdroj:	HLA. 92:224-230
ISSN:	2059-2302
DOI:	10.1111/tan.13325
Popis:	In the present study, the polymorphism in the 5'-upstream regulation region (5'-URR), coding region (exons 2-4), and the 3'-untranslated region (3'-UTR) of MICB gene were investigated for 150 healthy unrelated Jing individuals in Guangxi Zhuang Autonomous Region, by using PCR-SBT method. A total of 14 variation sites in the 5'-URR, 9 in coding region, and 6 in the 3'-UTR were detected in the Jing population. The MICB gene seems to present two different lineages showing functional variations mainly in nucleotides of the promoter region. Nineteen different MICB extended haplotypes (EHs) encompassing the 5'-URR, exons 2-4, and 3'-UTR were found in this population, and the most frequent was EH2 (20.33%). The findings here are of importance for future studies on the potential role of regulation region of MICB gene in disease association, transplantation, viral infection, and tumor progression among Jing population.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be612bc4c58a28764e5d62bd43799a19 https://doi.org/10.1111/tan.13325 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.