Mutational signatures among young-onset testicular cancers
Autor: | Cheryl E. Peters, Nicole E. Mealey, Darren R. Brenner, Dylan E O'Sullivan, Daniel Y. C. Heng |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Adult
Male Oncology medicine.medical_specialty Testicular neoplasms Mutational signatures Genomics Biology QH426-470 Young Adult 03 medical and health sciences 0302 clinical medicine Somatic mutations Internal medicine medicine Genetics Humans Young adult Genetics (clinical) Testicular cancer 030304 developmental biology 0303 health sciences Genome Human Incidence (epidemiology) Neoplasms Germ Cell and Embryonal medicine.disease RC31-1245 Human genetics 3. Good health Chewing tobacco Young-onset 030220 oncology & carcinogenesis Mutation Etiology Age of onset Research Article |
Zdroj: | BMC Medical Genomics, Vol 14, Iss 1, Pp 1-9 (2021) BMC Medical Genomics |
ISSN: | 1755-8794 |
Popis: | Background Incidence of testicular cancer is highest among young adults and has been increasing dramatically for men born since 1945. This study aimed to elucidate the factors driving this trend by investigating differences in mutational signatures by age of onset. Methods We retrieved somatic variant and clinical data pertaining to 135 testicular tumors from The Cancer Genome Atlas. We compared mutational load, prevalence of specific mutated genes, mutation types, and mutational signatures between age of onset groups ( Results Mutational load was significantly higher among older-onset tumors (p p > 0.05). Signatures 1, 8 and 29 were more common among young-onset tumors, while signatures 11 and 16 had higher prevalence among older-onset tumors (p Conclusions Signature contributions differ by age with signatures 1, 8 and 29 were more common among younger-onset tumors. While these signatures are connected with endogenous deamination of 5-methylcytosine, late replication errors and chewing tobacco, respectively, additional research is needed to further elucidate the etiology of young-onset testicular cancer. Large studies of mutational signatures among young-onset patients are required to understand epidemiologic trends as well as inform targeted prevention and treatment strategies. |
Databáze: | OpenAIRE |
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