Leukocyte telomere length in mild cognitive impairment and Alzheimer's disease patients
| Autor: | Daniela Scarabino, Rosa Maria Corbo, Giuseppe Gambina, Elisabetta Broggio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Apolipoprotein E Oncology Aging Disease Neuropsychological Tests Biochemistry Pathogenesis Cognition 0302 clinical medicine Endocrinology Telomere erosion Risk Factors 80 and over Leukocytes Cognitive decline Telomere Shortening Aged 80 and over Middle Aged Telomere Mental Status and Dementia Tests Alzheimer's disease (AD) Disease Progression Female Alzheimer's disease medicine.medical_specialty Alzheimer's disease (AD) Amnestic mild cognitive impairment Leukocyte telomere length Telomere erosion Amnestic mild cognitive impairment Leukocyte telomere length Aged Alzheimer Disease Case-Control Studies Cognitive Dysfunction Humans Linear Models Molecular Biology Genetics Cell Biology 03 medical and health sciences Internal medicine medicine Effects of sleep deprivation on cognitive performance business.industry Case-control study medicine.disease 030104 developmental biology business 030217 neurology & neurosurgery |
| Zdroj: | Experimental gerontology 98 (2017): 143–147. doi:10.1016/j.exger.2017.08.025 info:cnr-pdr/source/autori:Scarabino, Daniela; Broggio, Elisabetta; Gambina, Giuseppe; Corbo, Rosa Maria/titolo:Leukocyte telomere length in mild cognitive impairment and Alzheimer's disease patients./doi:10.1016%2Fj.exger.2017.08.025/rivista:Experimental gerontology/anno:2017/pagina_da:143/pagina_a:147/intervallo_pagine:143–147/volume:98 |
| DOI: | 10.1016/j.exger.2017.08.025 |
| Popis: | Numerous studies have reported an association between shortened leukocyte telomere length (LTL) and increased risk of Alzheimer's disease (AD). In this study we investigated the relationship between LTL and AD development, including in the analysis patients with amnestic mild cognitive impairment (aMCI), a clinical entity considered prodromal of AD. LTL (T/S ratio) was measured in patients with AD (n=61) or aMCI (n=46), and compared with LTL of age-matched controls (n=56). Significant LTL differences were observed between controls, aMCI and AD patients (p |
| Databáze: | OpenAIRE |
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