Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test

Autor: En-Li Chen, Tsung-I Chen, Vaishnavi Seenan, Yin-Jeh Tzeng, I-Hsin Lin, Jane Shiung, Tung-Wu Chang, Yun-Chen Chiang, Yu-Wei Tseng, Yan-Shu Jhang, Chueh-Yu Lin, Ming-Hua Chen, Shang-Chi Lai
Rok vydání: 2017
Předmět:
Blood Glucose
0301 basic medicine
Pharmaceutical Science
Salvia miltiorrhiza
Pharmacology
Blood Urea Nitrogen
Superoxide dismutase
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
danshen
salvia miltiorrhiza
Malondialdehyde
Drug Discovery
Animals
Lactic Acid
skin and connective tissue diseases
prolongation of exercise
Blood urea nitrogen
Fatigue
Swimming
Dose-Response Relationship
Drug
biology
Superoxide Dismutase
Chemistry
lcsh:RM1-950
General Medicine
glucose and lactate reduction
Disease Models
Animal
lcsh:Therapeutics. Pharmacology
030104 developmental biology
Complementary and alternative medicine
Serum glucose
Abietanes
Tanshinone IIA
biology.protein
Molecular Medicine
Vehicle control
Female
human activities
030217 neurology & neurosurgery
Behavioural despair test
Zdroj: Pharmaceutical Biology, Vol 55, Iss 1, Pp 2264-2269 (2017)
ISSN: 1744-5116
1388-0209
DOI: 10.1080/13880209.2017.1401648
Popis: Context: Tanshinone IIA (Tan IIA) is a constituent of Danshen Salvia miltiorrhiza Bunge (Lamiaceae); however, its antifatigue activity remains unclear. Objective: To study the antifatigue properties of Tan IIA and its underlying mechanisms. Materials and methods: In program I, three mouse groups were separately subjected to three gavages with 0, 1 and 6 mg/kg Tan IIA and forced swimming test (FST) weekly for 8 weeks; in program II, one gavage with 0, 2 and 10 mg/kg Tan IIA was administered plus FST weekly for 4 weeks. Serum glucose, lactate, superoxide dismutase (SOD), malondialdehyde (MDA) and blood urea nitrogen (BUN) were determined after final FST. Results: Tan IIA significantly prolonged swimming durations in program I but not in program II. Swimming times were 3208 ± 1054 and 2443 ± 1054 s for the 1 and 6 mg/kg treatments and 856 ± 292 s for the vehicle control. The two doses significantly reduced serum glucose levels (40.3 ± 8.5 and 60.0 1 ± 11.8 mg/kg) and lactate levels (61.3 ± 27.5 and 68.8 ± 8.5 mg/kg) in treated mice compared with those in control mice (137.5 ± 38.6 mg/kg and 122.7 ± 18.2 mg/kg, respectively). However, no significant differences were observed regarding SOD, MDA or BUN levels. Discussion and conclusions: Tan IIA has antifatigue activity and is associated with reductions in serum glucose and lactate levels. Further studies should assess muscle hypertrophy and efficient aerobic glycolysis caused by Tan IIA. Tan IIA has potential as a pharmacological agent for fatigue resistance.
Databáze: OpenAIRE
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