Non-invasive tissue temperature measurements based on quantitative diffuse optical spectroscopy (DOS) of water
| Autor: | Bruce J. Tromberg, Albert E. Cerussi, Sean Merritt, So Hyun Chung, Jason R. Ruth |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Optics and Photonics Materials science Absorption of water Absorption spectroscopy Spectral line Article Absorption Body Temperature Hemoglobins Young Adult Nuclear magnetic resonance Stress Physiological Bound water Humans Scattering Radiation Radiology Nuclear Medicine and imaging Spectroscopy Muscle Skeletal Absolute zero Isosbestic point Spectroscopy Near-Infrared Radiological and Ultrasound Technology Phantoms Imaging Spectrum Analysis Thermistor Temperature Water Cold Temperature Forearm Thermography Oxyhemoglobins Algorithms |
| Zdroj: | Chung, SH; Cerussi, AE; Merritt, SI; Ruth, J; & Tromberg, BJ. (2010). Non-invasive tissue temperature measurements based on quantitative diffuse optical spectroscopy (DOS) of water. Physics in Medicine and Biology, 55(13), 3753-3765. doi: 10.1088/0031-9155/55/13/012. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9803r9kz |
| DOI: | 10.1088/0031-9155/55/13/012. |
| Popis: | We describe the development of a non-invasive method for quantitative tissue temperature measurements using Broadband diffuse optical spectroscopy (DOS). Our approach is based on well-characterized opposing shifts in near-infrared (NIR) water absorption spectra that appear with temperature and macromolecular binding state. Unlike conventional reflectance methods, DOS is used to generate scattering-corrected tissue water absorption spectra. This allows us to separate the macromolecular bound water contribution from the thermally induced spectral shift using the temperature isosbestic point at 996 nm. The method was validated in intralipid tissue phantoms by correlating DOS with thermistor measurements (R = 0.96) with a difference of 1.1 0.91 °C over a range of 28-48 °C. Once validated, thermal and hemodynamic (i.e. oxy-and deoxy-hemoglobin concentration) changes were measured simultaneously and continuously in human subjects (forearm) during mild cold stress. DOS-measured arm temperatures were consistent with previously reported invasive deep tissue temperature studies. These results suggest that DOS can be used for non-invasive, co-registered measurements of absolute temperature and hemoglobin parameters in thick tissues, a potentially important approach for optimizing thermal diagnostics and therapeutics. © 2010 Institute of Physics and Engineering in Medicine. |
| Databáze: | OpenAIRE |
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