LYMPHOCYTE ACTIVATION IN SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND CYTOMEGALOVIRUS INFECTIONS
| Autor: | G. B. Thurman, A. Ahmed, D. M. Strong, R. C. Knudsen, W. R. Grace, K. W. Sell |
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| Rok vydání: | 1973 |
| Předmět: |
Immunology
Congenital cytomegalovirus infection Cytomegalovirus Biology Lymphocyte Activation Tritium Measles Article Virus Subacute sclerosing panencephalitis Cell Line Measles virus Mice Immune system Antigen medicine Animals Humans Immunology and Allergy Lymphocytes Macrophage Migration-Inhibitory Factors Immunity Cellular Macrophages virus diseases biology.organism_classification medicine.disease Virology Antibody Formation Cytomegalovirus Infections Subacute Sclerosing Panencephalitis Encephalitis HeLa Cells Thymidine |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.138.4.839 |
| Popis: | Efforts to stimulate lymphocytes from measles seropositive and two patients with subacute sclerosing panencephalitis (SSPE) with either commercially available measles virus or virus isolated from a known case of SSPE failed to show any significant data using a microculture assay. Similar results were obtained using lymphocytes from two patients with active cytomegalovirus (CMV) infections and CMV seropositive individuals using CMV suspensions. On the other hand, lymphocytes from the patients with subacute sclerosing panencephalitis exhibited in vitro blastogenesis in culture with SSPE virus-infected HeLa cells. Similarly, lymphocytes from the CMV-infected patients demonstrated blastogenesis when cocultivated with CMV-infected WI-38 cells. This affords a new method for determining the cell-mediated immune capacity of patients with "slow" virus diseases. |
| Databáze: | OpenAIRE |
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