Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice
| Autor: | D A Cohen, D G Karounos, J S Bryson |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.medical_treatment Injections Subcutaneous Insulin analog Autoimmunity Hypoglycemia Prediabetic State Subcutaneous injection Mice Mice Inbred NOD Internal medicine Diabetes mellitus medicine Animals Insulin Lymphocytes Pancreas NOD mice geography geography.geographical_feature_category biology business.industry General Medicine Islet medicine.disease Insulin receptor Endocrinology Diabetes Mellitus Type 1 biology.protein Female business Research Article |
| Zdroj: | The Journal of clinical investigation. 100(6) |
| ISSN: | 0021-9738 |
| Popis: | The purpose of this study was to determine the relative importance of the metabolic effects of insulin for diabetes prevention by administering insulin or an inactive insulin analog by daily subcutaneous injections to prediabetic mice. A recombinant monomeric human insulin analog, which does not bind to the insulin receptor as a consequence of an alteration of a single amino acid at position 25 of the B chain, was shown to be equally effective at diabetes prevention as was intact insulin. In contrast to native insulin, the insulin analog did not cause hypoglycemia after subcutaneous injection. The insulin analog, however, protected young adult mice from diabetes, even when it was initiated after the onset of extensive lymphocytic infiltration of the islets. Thus, preventative therapy by daily subcutaneous injections of insulin does not require the hypoglycemic response, or binding to the insulin receptor to prevent the onset of type I diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|