The Concentration of beta-Carotene in Human Adipocytes, but Not the Whole-Body Adipocyte Stores, Is Reduced in Obesity
| Autor: | Peter Strålfors, Anita Öst, Martin Östh, Preben Kjølhede |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Cell Physiology Medicin och hälsovetenskap Anatomy and Physiology Adipose tissue lcsh:Medicine Type 2 diabetes Biochemistry Medical and Health Sciences Body Mass Index chemistry.chemical_compound Insulin resistance Endocrinology Diabetes mellitus Adipocyte Internal medicine medicine Adipocytes Humans Tissue Distribution Obesity lcsh:Science Biology Triglycerides Nutrition Diabetic Endocrinology Multidisciplinary business.industry lcsh:R Vitamins Middle Aged Diabetes Mellitus Type 2 medicine.disease beta Carotene Isoprenoids Lipid Metabolism Lipids Metabolism chemistry Cholesteryl ester Medicine lcsh:Q Female Insulin Resistance business Body mass index Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 9, Iss 1, p e85610 (2014) |
| Popis: | We have examined the concentration of beta-carotene in the fat of isolated abdominal subcutaneous adipocytes obtained from lean (BMIless than23 kg/m(2)), non-obese with higher BMI (23 less than= BMIless than28 kg/m(2)), obese (BMI greater than= 28 kg/m(2)), and from a group of obese subjects with type 2 diabetes. The concentration of b-carotene was 50% lower in the adipocytes from the obese and obese/diabetic groups compared with the lean and non-obese groups. Interestingly, the total amount of beta-carotene in the adipocyte stores of each subject was constant among all groups. Triacylglycerol constituted 92 +/- 1% (by weight) of the adipocyte lipids in the lean group and this was increased to 99 +/- 2% in the obese group with diabetes (pless than0.05). The concentration of cholesteryl esters was in all cases less than0.1 g per 100 g of total lipids, demonstrating that mature human adipocytes have negligible stores of cholesteryl ester. Our findings demonstrate that adipocyte concentrations of beta-carotene are reduced in obese subjects. The lower concentrations in adipocytes from subjects with type 2 diabetes apparently reflect subjects obesity. Our finding that whole-body stores of beta-carotene in adipocytes are constant raises new questions regarding what function it serves, as well as the mechanisms for maintaining constant levels in the face of varied adipose tissue mass among individuals over a period of time. |
| Databáze: | OpenAIRE |
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