Two new naphthoate derivatives from Morinda officinalis
| Autor: | Yuying Zhang, Jin-Hai Yu, Hui-Juan Zhai, Guo-Hua Ye, Hua Zhang, Jun-Juan Xue |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
Rubiaceae biology 010405 organic chemistry Stereochemistry Dimer Organic Chemistry Pharmaceutical Science General Medicine biology.organism_classification 01 natural sciences 0104 chemical sciences Analytical Chemistry Morinda officinalis 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Monomer Complementary and alternative medicine chemistry Drug Discovery Molecular Medicine Cytotoxicity |
| Zdroj: | Journal of Asian Natural Products Research. 22:1018-1023 |
| ISSN: | 1477-2213 1028-6020 |
| DOI: | 10.1080/10286020.2019.1670648 |
| Popis: | Two new naphthoate derivatives, including a symmetrical dimer (1) and a monomer (2), were separated from the roots of Morinda officinalis var. hirsuta. Their structures were characterized on the basis of spectroscopic means especially MS and NMR methods. Biological evaluations revealed that the two compounds did not show inhibition against both cholinesterases AChE and BChE, while the dimer (1) did exhibit moderate growth inhibitory activity toward one human osteosarcoma cell line U2OS with an IC50 value of 18.5 ± 1.1 μM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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