Plasmatic estradiol concentration in the mid-luteal phase is a good prognostic factor for clinical and ongoing pregnancies, during stimulated cycles of in vitro fertilization
| Autor: | Rodopiano de Souza Florêncio, Melaynne S B Meira, Marcos V da Cunha, Mylena N C R Camarço, Eduardo Camelo de Castro, Marta C C F Finotti, Vinicius A de Oliveira |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pregnancy Rate Pregnancy Tests medicine.drug_class medicine.medical_treatment Fertilization in Vitro 02 engineering and technology Luteal Phase Luteal phase Andrology Young Adult 03 medical and health sciences luteal phase support 0302 clinical medicine Ovulation Induction Predictive Value of Tests Pregnancy In vitro fertilization 0202 electrical engineering electronic engineering information engineering Humans Medicine Sperm Injections Intracytoplasmic estradiol in the luteal phase Ovarian reserve reproductive and urinary physiology 030219 obstetrics & reproductive medicine In vitro fertilisation Estradiol business.industry Estradiol valerate 020206 networking & telecommunications Embryo Middle Aged Prognosis mid-luteal phase medicine.disease Embryo transfer Case-Control Studies Infertility Female Original Article Gonadotropin business hormones hormone substitutes and hormone antagonists Maternal Age medicine.drug |
| Zdroj: | JBRA Assisted Reproduction |
| ISSN: | 1518-0557 |
| DOI: | 10.5935/1518-0557.20180005 |
| Popis: | Objective To evaluate the predictive efficiency of serum estradiol (E2) concentration in the mid-luteal phase regarding chemical, clinical, and ongoing pregnancies, in patients subjected to IVF/ICSI with fresh embryo transfer. Methods One hundred and forty-three patients undergoing IVF/ICSI met all the inclusion criteria for the present study. Most of the patients used antagonists, final maturation was achieved with recombinant chorionic gonadotrophin (HCG), and embryo transfer took place on days 3 to 5, but mostly on day 4. The luteal phase was supplemented with estradiol valerate 6 mg/day and vaginal micronized progesterone 600 mg/day. There was no exclusion of patients in the embryo transfer group due to age or ovarian reserve. All patients with estradiol and chorionic gonadotrophin (βHCG) dosage on the day of transfer, day 7, were included. We assessed the following variables, initially regarding age: number of eggs collected, formed embryos, embryos transferred, day of transfer, transfer type, estradiol and chorionic gonadotropin. Next, we evaluated these elements at three different ranges of estradiol concentrations (500 pg/ml), comparing these parameters in pregnant (P) and non-pregnant (NP) patients. Results Data analysis by age group in P and NP patients showed significant differences in the mean values of the variables E2 and βHCG, TD7. Mean serum estradiol levels in P and NP in the three age groups were: 39 years, 841/394 p=0.0012. There was also a significant difference in pregnancy rates in the group >500 pg/ml of estradiol concentration (63.4%, p=0.0096). The likelihood of chemical and clinical abortions for the estradiol ranges were: 38.46%, involving the two first ranges versus 15.15% for a concentration >500 pg/ml, p=0.0412 and 5.26% for a concentration >900 pg/ml, p=0.0105. The Pearson correlation coefficient for HCG and estradiol was r = 0.5108. Conclusion This study showed the prognostic value of E2 in the mid-luteal phase (TD7) for chemical, clinical, and ongoing pregnancies, and its concentration suggested that there is a moderately positive correlation with βHCG levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|