Role of Apolipoproteins and α-Synuclein in Parkinson’s Disease
| Autor: | Fatemeh Nouri Emamzadeh |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Apolipoprotein E medicine.medical_specialty Parkinson's disease Apolipoprotein B Substantia nigra Neuroprotection Article 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Internal medicine Dopaminergic Cell medicine Animals Humans α-Synuclein Alpha-synuclein biology business.industry Dopaminergic Parkinson Disease General Medicine medicine.disease Apolipoproteins Cholesterol 030104 developmental biology Endocrinology nervous system chemistry alpha-Synuclein Parkinson’s disease biology.protein business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Molecular Neuroscience |
| ISSN: | 1559-1166 0895-8696 |
| Popis: | Parkinson’s disease (PD) is a progressive brain disorder that interferes with activities of normal life. The main pathological feature of this disease is the loss of more than 80% of dopamine-producing neurons in the substantia nigra (SN). Dopaminergic neuronal cell death occurs when intraneuronal, insoluble, aggregated proteins start to form Lewy bodies (LBs), the most important component of which is a protein called α-synuclein (α-syn). α-Syn structurally contains hexameric repeats of 11 amino acids, which are characteristic of apolipoproteins and thus α-syn can also be considered an apolipoprotein. Moreover, apolipoproteins seem to be involved in the incidence and development of PD. Some apolipoproteins such as ApoD have a neuroprotective role in the brain. In PD, apoD levels increase in glial cells surrounding dopaminergic cells. However, elevated levels of some other apolipoproteins such as ApaA1 and ApoE are reported as a vulnerability factor of PD. At present, when a clinical diagnosis of PD is made, based on symptoms such as shaking, stiff muscles and slow movement, serious damage has already been done to nerve cells of the SN. The diagnosis of PD in its earlier stages, before this irreversible damage, would be of enormous benefit for future treatment strategies designed to slow or halt the progression of PD. This review presents the roles of apolipoproteins and α-syn in PD and how some of them could potentially be used as biomarkers for PD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink