The effects of lutein on respiratory health across the life course
| Autor: | Oscar H. Franco, Janine F. Felix, Wichor M. Bramer, Taulant Muka, Sirwan K.L. Darweesh, Myrte J. Tielemans, Anna Vitezova, Guy Brusselle, Debora Melo van Lent, Eduardo M. Moreira, Rajiv Chowdhury, Jessica C. Kiefte-de Jong, Elisabeth T.M. Leermakers |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Pediatrics medicine.medical_specialty Lutein Longitudinal study Cross-sectional study Endocrinology Diabetes and Metabolism Respiratory System Respiratory Tract Diseases Antioxidants law.invention 03 medical and health sciences chemistry.chemical_compound Randomized controlled trial SDG 3 - Good Health and Well-being Zeaxanthins law medicine Humans Respiratory function Longitudinal Studies Child Bronchopulmonary Dysplasia Randomized Controlled Trials as Topic Respiratory Sounds Asthma 030109 nutrition & dietetics Nutrition and Dietetics business.industry Infant Newborn Case-control study food and beverages medicine.disease Carotenoids eye diseases Cross-Sectional Studies chemistry Bronchopulmonary dysplasia Case-Control Studies Dietary Supplements business |
| Zdroj: | Clinical Nutrition ESPEN. 13:e1-e7 |
| ISSN: | 2405-4577 |
| DOI: | 10.1016/j.clnesp.2016.02.096 |
| Popis: | Summary Background Lutein, a fat-soluble carotenoid present in green leafy vegetables and eggs, has strong antioxidant properties and could therefore be important for respiratory health. Design We systematically reviewed the literature for articles that evaluated associations of lutein (intake, supplements or blood levels) with respiratory outcomes, published in Medline, Embase, Cochrane Central, PubMed, Web of Science and Google Scholar, up to August 2014. Results We identified one Randomized Control Trial (RCT), two longitudinal, four prospective and six cross-sectional studies. The individual studies obtained a Quality Score ranging between 3 and 9. Six studies were performed in children, which examined bronchopulmonary dysplasia (BPD), asthma and wheezing. In adults, 7 studies investigated asthma, respiratory function and respiratory mortality. The RCT found a borderline significant effect of lutein/zeaxanthin supplementation in neonates on the risk of BPD (OR 0.43 (95% CI 0.15; 1.17). No association was found between lutein intake or levels and respiratory outcomes in children. A case–control study in adults showed lower lutein levels in asthma cases. Three studies, with a prospective or longitudinal study design, in adults found a small but a significant positive association between lutein intake or levels and respiratory function. No association was found in the other two studies. In relation to respiratory mortality, one longitudinal study showed that higher lutein blood levels were associated with a decreased mortality (HR 0.77 (95% CI 0.60; 0.99), per SD increase in lutein). Conclusion The published literature suggests a possible positive association between lutein and respiratory health. However, the literature is scarce and most studies are of observational nature. |
| Databáze: | OpenAIRE |
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