Patients hospitalized because of small vessel vasculitides with renal involvement in the period 1975–95: organ involvement, anti‐neutrophil cytoplasmic antibodies patterns, seasonal attack rates and fluctuation of annual frequencies
Autor: | D Danielsson, M Tidman, C Svalander, R Olander |
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Rok vydání: | 1998 |
Předmět: |
Adult
Male Vasculitis medicine.medical_specialty IgA Vasculitis Churg-Strauss Syndrome Kidney Antibodies Antineutrophil Cytoplasmic Diagnosis Differential Age Distribution Seroepidemiologic Studies Internal medicine Epidemiology Internal Medicine Humans Medicine Sex Distribution Aged Retrospective Studies Anti-neutrophil cytoplasmic antibody Aged 80 and over Sweden business.industry Granulomatosis with Polyangiitis Retrospective cohort study Middle Aged medicine.disease Surgery Hospitalization Purpura Female Seasons medicine.symptom business Complication Microscopic polyangiitis Kidney disease |
Zdroj: | Journal of Internal Medicine. 244:133-141 |
ISSN: | 1365-2796 0954-6820 |
Popis: | Tidman M, Olander R, Svalander C, Danielsson D (Orebro Medical Center Hospital, Orebro and Sahlgrenska Hospital, Gothenburg, Sweden). Patients hospitalized because of small vessel vasculitides with renal involvement in the period 1975–95: organ involvement, anti-neutrophil cytoplasmic antibodies patterns, seasonal attack rates and fluctuation of annual frequencies. J Intern Med 1998; 244: 133–41. Objectives : To study organ involvement, anti-neutrophil cytoplasmic antibodies (ANCA) patterns, trends in yearly frequencies and seasonal variations of symptom onset in patients hospitalized because of small vessel vasculitides during a 21 year period (1975–95). Design A retrospective investigation was conducted of 138 patients hospitalized with a diagnosis of small vessel vasculitides, as defined by the Chapel Hill Consensus Conference, within the County of Orebro, a mixed urban and rural area of central Sweden. Setting Orebro Medical Center Hospital, Orebro, Sweden and two district hospitals within the County of Orebro, Sweden. Results During the studied period there were 19 patients with a diagnosis of Wegener's granulomatosis (WG), 70 patients with microscopic polyangiitis (MPA), 36 patients with renal limited vasculitis (RLV), two with Churge-Strauss vasculitis (C-S), seven with Henoch-Schonleins purpura (HSP) and four with essential cryoglobulinemic vasculitis (ECV). Renal involvement was present in 123 patients (89.1%). A positive c- and/or pANCA was found in nearly 90% of the 111 patients where sera were available. Calculations of frequency data, restricted to the primary catchment area for patients with ANCA associated vasculitis and renal involvement (WG, MPA, RLV) during a 21-year period (1975–95) gave a mean annual frequency of 1.6 per 100 000 adults (95% CI: 1.2–3.1); for this group of patients with the inclusion of those with C-S, HSP and ECV during the last 10 year period (1986–95) gave a mean annual frequency of 2.5 per 100 000 adults (95% CI: 1.7–3.4), for male adults 3 per 100 000 (95% CI: 1.6–4.4), and female adults 1.9 (95% CI: 0.9–2.8). A frequency peak of 6.3 per 100 000 was seen for men aged 55–64. A periodic fluctuation of the frequencies with peaks every 3–4 years was noted for patients with ANCA related vasculitis (WG, MPA, RLV) during the 21-year period 1975–95. Onset of symptoms was predominantly noticed during the winter months (December– February) for patients with a positive cANCA. Conclusion The observed frequencies in our study of patients with small vessel vasculitides were higher than those previously documented. We also showed a periodic fluctuation of the annual frequencies and a seasonal variation of symptom onset. |
Databáze: | OpenAIRE |
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