A Potential Role of the CD47/SIRPalpha Axis in COVID-19 Pathogenesis
| Autor: | Mark N. Wass, Denisa Bojkova, Katie-May McLaughlin, Sandra Ciesek, Jindrich Cinatl, Marco Bechtel, Martin Michaelis, Andreas Weigert, Florian Rothweiler, Joshua D. Kandler, Trang T. Le, Julian U. G. Wagner, Philipp Reus |
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| Přispěvatelé: | Publica |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
RM QH301-705.5 SIRPalpha Blotting Western coronavirus Blood Donors Bronchi CD47 Antigen Disease Microbiology Asymptomatic Polymerase Chain Reaction Severity of Illness Index Monocytes Pathogenesis Immune system Diabetes mellitus antiviral therapy Medicine Humans ddc:610 Biology (General) Receptors Immunologic CD47 Molecular Biology Pandemics QR355 biology business.industry Vascular disease SARS-CoV-2 Acute kidney injury COVID-19 Epithelial Cells General Medicine IAP medicine.disease Antigens Differentiation Healthy Volunteers Immunology biology.protein RNA Viral Antibody medicine.symptom Caco-2 Cells business Signal Transduction |
| Zdroj: | Current Issues in Molecular Biology Volume 43 Issue 3 Pages 86-1225 Current Issues in Molecular Biology, Vol 43, Iss 86, Pp 1212-1225 (2021) |
| ISSN: | 1467-3045 1467-3037 |
| Popis: | The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Most SARS-CoV-2 infections are mild or even asymptomatic. However, a small fraction of infected individuals develops severe, life-threatening disease, which is caused by an uncontrolled immune response resulting in hyperinflammation. However, the factors predisposing individuals to severe disease remain poorly understood. Here, we show that levels of CD47, which is known to mediate immune escape in cancer and virus-infected cells, are elevated in SARS-CoV-2-infected Caco-2 cells, Calu-3 cells, and air−liquid interface cultures of primary human bronchial epithelial cells. Moreover, SARS-CoV-2 infection increases SIRPalpha levels, the binding partner of CD47, on primary human monocytes. Systematic literature searches further indicated that known risk factors such as older age and diabetes are associated with increased CD47 levels. High CD47 levels contribute to vascular disease, vasoconstriction, and hypertension, conditions that may predispose SARS-CoV-2-infected individuals to COVID-19-related complications such as pulmonary hypertension, lung fibrosis, myocardial injury, stroke, and acute kidney injury. Hence, age-related and virus-induced CD47 expression is a candidate mechanism potentially contributing to severe COVID-19, as well as a therapeutic target, which may be addressed by antibodies and small molecules. Further research will be needed to investigate the potential involvement of CD47 and SIRPalpha in COVID-19 pathology. Our data should encourage other research groups to consider the potential relevance of the CD47/ SIRPalpha axis in their COVID-19 research. |
| Databáze: | OpenAIRE |
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