Association between the c.1564AT genetic polymorphism of the MDR1 gene and hepatocellular carcinoma in Chinese population
| Autor: | L. Wan, Hong-Xia Hui, Xiao-Wei Wang, Yi-Yuan Wan |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty China Carcinoma Hepatocellular Genotype DNA Mutational Analysis Biology Gastroenterology Polymerase Chain Reaction Polymorphism Single Nucleotide law.invention Asian People Gene Frequency law Risk Factors Internal medicine Genetic model Genetics medicine Humans Genetic Predisposition to Disease ATP Binding Cassette Transporter Subfamily B Member 1 Allele Deoxyribonucleases Type II Site-Specific Molecular Biology Gene Allele frequency Polymerase chain reaction Alleles Genetic association Aged Binding Sites Liver Neoplasms General Medicine Middle Aged medicine.disease Hepatocellular carcinoma Female |
| Zdroj: | Genetics and molecular research : GMR. 13(3) |
| ISSN: | 1676-5680 |
| Popis: | UNLABELLED The objective of this study was to evaluate the influence of c.1564A>T genetic polymorphisms in the multidrug resistance 1 gene (MDR1) on hepatocellular carcinoma (HCC) susceptibility through association analysis. A total of 632 HCC patients and 645 cancer-free controls were enrolled in this study. The c.1564A>T genetic polymorphisms were genotyped by created restriction site-polymerase chain reaction (CRS-PCR) and confirmed using DNA sequencing methods. The potential associations of c.1564A>T genetic polymorphisms with the risk of HCC were analyzed by different genetic models. Statistically significantly increased risks of HCC were detected in the homozygote comparison (TT versus AA: OR = 1.70, 95%CI = 1.17-2.45, χ(2) = 7.99, P = 0.005), recessive model (TT versus AT/AA OR = 1.64, 95%CI = 1.15-2.33, χ(2) = 7.66, P = 0.006), and allele contrast (T versus A: OR = 1.23, 95%CI = 1.04-1.45, χ(2) = 6.09, P = 0.014). Our data suggest that the genotypes/alleles from c.1564A>T genetic polymorphisms are statistically associated with HCC risk. The allele-T and genotype TT may contribute to susceptibility to HCC in the Chinese Han population. |
| Databáze: | OpenAIRE |
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