Chitosan-based nanotherapeutics for ovarian cancer treatment

Autor:	Leila Alizadeh, Mohammad Rahmati-Yamchi, Amir Zarebkohan, Amir Ajjoolabady, Roya Salehi
Rok vydání:	2019
Předmět:	Poor prognosis Polymers Pharmaceutical Science Antineoplastic Agents Gene delivery Chitosan chemistry.chemical_compound Drug Delivery Systems Chitin Animals Humans Medicine Ovarian Neoplasms business.industry Prognosis medicine.disease Tumour site chemistry Drug delivery Cancer research Nanoparticles Female Nanocarriers business Ovarian cancer
Zdroj:	Journal of Drug Targeting. 27:839-852
ISSN:	1029-2330 1061-186X
DOI:	10.1080/1061186x.2018.1564923
Popis:	Chitosan is one of the low toxic and natural polysaccharides which is obtained from deacetylation of chitin. Chitosan-based nanoparticles have good biodegradation and bio-distribution in the biological milieu, which have made it as one of the most attractive nanocarriers for delivering different therapeutic agents to the tumour cells especially ovarian cancer cell lines. Chitosan can covalently and non-covalently be modified and attached to different polymers and targeting moieties through its free amine groups and reach to the tumour site through passive and active targeting strategies. Ovarian cancer is one of the most common and resistant cancers with poor prognosis among women, which scientists are trying to prepare new methods for improving their treatments outcomes in past decades. In this article, we tried to take an overview on the recent developments in different modifications of chitosan-based nanoformulations, which are utilised for ovarian cancer therapy.
Databáze:	OpenAIRE
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