Improved pregnancy rates with luteinizing hormone supplementation in patients undergoing ovarian stimulation for IVF
| Autor: | Nicole D. Paterson, Shu C. Foong, Calvin Greene |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Pregnancy Rate medicine.medical_treatment Controlled ovarian hyperstimulation Fertilization in Vitro Andrology Cohort Studies Follicle-stimulating hormone Follicle Ovarian Follicle Ovulation Induction Pregnancy Internal medicine Genetics medicine Humans Embryo Implantation Ovarian follicle Assisted Reproduction Technologies Genetics (clinical) Retrospective Studies In vitro fertilisation business.industry Obstetrics and Gynecology General Medicine Luteinizing Hormone Pregnancy rate medicine.anatomical_structure Endocrinology Reproductive Medicine Oocytes Ovulation induction Female Follicle Stimulating Hormone Human Luteinizing hormone business Developmental Biology |
| Zdroj: | Journal of assisted reproduction and genetics. 29(7) |
| ISSN: | 1573-7330 |
| Popis: | Luteinizing hormone (LH) is believed to play a role in follicle maturation during the natural cycle. However, the need for co-treatment with recombinant LH (rLH) for controlled ovarian stimulation is controversial.The primary objective of our study was to determine if pregnancy rates are improved when rLH is used in addition to rFSH for ovarian stimulation. Secondary outcomes were fertilization rate, implantation rate and live birth rate.A retrospective cohort study was performed of 1565 IVF or ICSI cycles. Outcomes were compared between ovarian stimulation cycles from 2007 when rLH and rFSH was used (n = 765) to 2006 when rFSH only was used (n-800).Improved outcomes were found for rLH + rFSH versus rFSH alone for; pregnancy rate (61% and 54% respectively, p = 0.006), live birth rate (49% and 42% respectively, P = 0.01), fertilization rate (74% versus 72% respectively, p = 0.04 and implantation rate (41% versus 37% respectively, p = 0.03).Our large retrospective cohort study showed an improved pregnancy rate and live birth rate with rLH supplementation. This was associated with an improved fertilization and implantation rate and therefore may reflect an improvement in oocyte quality and/or uterine receptivity. |
| Databáze: | OpenAIRE |
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