Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex
| Autor: | Maciej M. Jankowski, Bshara Awwad, Israel Nelken |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
stimulus-specific adaptation
Cognitive Neuroscience media_common.quotation_subject Population Biology Auditory cortex 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Perception Animals rat AcademicSubjects/MED00385 education 030304 developmental biology media_common Auditory Cortex 0303 health sciences education.field_of_study Neuronal Plasticity Mechanism (biology) AcademicSubjects/SCI01870 Gap detection Rats Auditory Perception AcademicSubjects/MED00310 Original Article Female gap detection Neuroscience short-term plasticity 030217 neurology & neurosurgery |
| Zdroj: | Cerebral Cortex (New York, NY) |
| ISSN: | 1460-2199 1047-3211 |
| Popis: | The ability to detect short gaps in noise is an important tool for assessing the temporal resolution in the auditory cortex. However, the mere existence of responses to temporal gaps bounded by two short broadband markers is surprising, because of the expected short-term suppression that is prevalent in auditory cortex. Here, we used in-vivo intracellular recordings in anesthetized rats to dissect the synaptic mechanisms that underlie gap-related responses. When a gap is bounded by two short markers, a gap termination response was evoked by the onset of the second marker with minimal contribution from the offset of the first marker. Importantly, we show that the gap termination response was driven by a different (potentially partially overlapping) synaptic population than that underlying the onset response to the first marker. This recruitment of additional synaptic resources is a novel mechanism contributing to the important perceptual task of gap detection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|