The Lateral Hypothalamic and BNST GABAergic Projections to the Anterior Ventrolateral Periaqueductal Gray Regulate Feeding
| Autor: | Hao Wang, Xiaomeng Wang, Hongbin Yang, Xiaotong Wu, Yu-Dong Zhou, Shumin Duan, Haifeng Xu, Huifang Lou, Libiao Pan, Yi-Jun Liu, Huan Ma, Yang He, Sijia Hao, Wang Xi, Han Xu |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Lateral hypothalamus Biology Optogenetics General Biochemistry Genetics and Molecular Biology Midbrain 03 medical and health sciences Mice 0302 clinical medicine Neural Pathways Biological neural network Animals Periaqueductal Gray GABA-A Receptor Agonists GABAergic Neurons Clozapine lcsh:QH301-705.5 Muscimol Body Weight Central Amygdaloid Nucleus Feeding Behavior Stria terminalis 030104 developmental biology lcsh:Biology (General) Hypothalamus Hypothalamic Area Lateral GABAergic Septal Nuclei Neuroscience 030217 neurology & neurosurgery Homeostasis Antipsychotic Agents |
| Zdroj: | Cell Reports, Vol 28, Iss 3, Pp 616-624.e5 (2019) |
| ISSN: | 2211-1247 |
| Popis: | Summary: Overeating is a serious issue in modern society, causing many health problems, including obesity. Although the hypothalamus has been previously identified as the key brain structure that regulates body weight homeostasis, the downstream pathways and non-canonical neural circuitry involved in feeding behavior remain largely uncharacterized. Here, we discover that suppressing the activity of GABAergic cells in the anterior ventrolateral periaqueductal gray (vlPAG), whether directly or through long-projection GABAergic inputs from either the bed nucleus of the stria terminalis (BNST) or the lateral hypothalamus (LH), is sufficient to promptly induce feeding behavior in well-fed mice. In contrast, optogenetic activation of these cells interrupts food intake in starved mice. Long-term chemogenetic manipulation of vlPAG GABAergic cell activity elicits a corresponding change in mouse body weight. Our studies reveal distinct midbrain GABAergic pathways and highlight an important role of GABAergic cells in the anterior vlPAG in feeding behavior. : Hao et al. uncovered an important role of the GABAergic cells in the anterior ventrolateral periaqueductal gray (vlPAG) and two distinct midbrain GABAergic pathways (the lateral hypothalamus-vlPAG and BNST-vlPAG) in regulation of feeding behavior. Keywords: feeding, vlPAG, GABAergic pathway, lateral hypothalamus, mice |
| Databáze: | OpenAIRE |
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