Stent interventions for pulmonary artery stenosis improve bi-ventricular flow efficiency in a swine model
| Autor: | Alejandro Roldán-Alzate, Christopher J. François, Gregory P. Barton, Ryan Pewowaruk, Cody Johnson, Luke Lamers, J. Carter Ralphe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system Heart disease Computed Tomography Angiography Ventricular Dysfunction Right medicine.medical_treatment Sus scrofa Magnetic Resonance Imaging Cine Pulmonary Artery 030204 cardiovascular system & hematology Pediatrics Ventricular Function Left 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine.artery Internal medicine medicine Animals Stenosis Pulmonary Artery Radiology Nuclear Medicine and imaging cardiovascular diseases Angiology Congenital heart disease 4D flow MRI Ejection fraction Radiological and Ultrasound Technology medicine.diagnostic_test Pulmonary artery stenosis business.industry Research Endovascular Procedures Myocardial Perfusion Imaging Stent Magnetic resonance imaging Recovery of Function medicine.disease Myocardial Contraction Disease Models Animal Stenosis lcsh:RC666-701 Pulmonary artery Ventricular Function Right Cardiology cardiovascular system Right ventricle Stents Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiovascular Magnetic Resonance, Vol 23, Iss 1, Pp 1-11 (2021) Journal of Cardiovascular Magnetic Resonance |
| Popis: | Background Branch pulmonary artery (PA) stenosis (PAS) commonly occurs in patients with congenital heart disease (CHD). Prior studies have documented technical success and clinical outcomes of PA stent interventions for PAS but the impact of PA stent interventions on ventricular function is unknown. The objective of this study was to utilize 4D flow cardiovascular magnetic resonance (CMR) to better understand the impact of PAS and PA stenting on ventricular contraction and ventricular flow in a swine model of unilateral branch PA stenosis. Methods 18 swine (4 sham, 4 untreated left PAS, 10 PAS stent intervention) underwent right heart catheterization and CMR at 20 weeks age (55 kg). CMR included ventricular strain analysis and 4D flow CMR. Results 4D flow CMR measured inefficient right ventricular (RV) and left ventricular (LV) flow patterns in the PAS group (RV non-dimensional (n.d.) vorticity: sham 82 ± 47, PAS 120 ± 47; LV n.d. vorticity: sham 57 ± 5, PAS 78 ± 15 p p p Conclusion These results describe previously unknown consequences of PAS on ventricular function in an animal model of unilateral PA stenosis and show that PA stent interventions improve ventricular flow efficiency. This study also highlights the sensitivity of 4D flow CMR biomarkers to detect earlier ventricular dysfunction assisting in identification of patients who may benefit from PAS interventions. |
| Databáze: | OpenAIRE |
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