Early dyspnoea relief in acute heart failure: prevalence, association with mortality, and effect of rolofylline in the PROTECT Study

Autor: Marco Metra, John R. Teerlink, John G.F. Cleland, Daniel M. Bloomfield, Gang Jia, Piotr Ponikowski, Beth A. Davison, Howard C. Dittrich, George A. Mansoor, Paul DeLucca, Gad Cotter, Adriaan A. Voors, Michael M. Givertz, Barry M. Massie, Christopher M. O'Connor
Přispěvatelé: Cardiovascular Centre (CVC)
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
Heart disease
Rolofylline
chemistry.chemical_compound
Weight loss
IN-HOSPITAL MORTALITY
Prospective Studies
Diuretics
Infusions
Intravenous
Prospective cohort study
Aged
80 and over
A(1) RECEPTOR ANTAGONIST
INTENSIVE-CARE MEDICINE
Hazard ratio
Middle Aged
EUROPEAN-SOCIETY
Treatment Outcome
Acute Disease
Cardiology
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
CLINICAL-TRIALS
medicine.medical_specialty
RANDOMIZED CONTROLLED-TRIALS
Adenosine A1 Receptor Antagonists
Double-Blind Method
Internal medicine
Dyspnoea
END-POINTS
medicine
Humans
OF-CARDIOLOGY
Aged
Heart Failure
business.industry
Surrogate endpoint
Acute heart failure. Diuretics
Acute heart failure
Length of Stay
WORSENING RENAL-FUNCTION
medicine.disease
Confidence interval
Surgery
Dyspnea
chemistry
Xanthines
Heart failure
business
TASK-FORCE
Zdroj: European Heart Journal, 32(12), 1519-1534. Oxford University Press
ISSN: 0195-668X
Popis: Aims Dyspnoea and pulmonary and/or peripheral congestion are the most frequent manifestations of acute heart failure (AHF) and are important targets for therapy. We have assessed changes in dyspnoea, their relationship with mortality, and the effects of the adenosine A1 receptor antagonist rolofylline on these endpoints in patients enrolled in the PROTECT trial.Methods and results PROTECT was a prospective, double-blind, placebo-controlled study assessing the effect of rolofylline in patients hospitalized for AHF with dyspnoea, fluid overload, increased plasma natriuretic peptides, and mild-to-moderate renal dysfunction. Early dyspnoea relief, prospectively defined as moderately or markedly better dyspnoea at both 24 and 48 h after the start of study drug administration, occurred in 49.8% of the patients. Early dyspnoea relief was associated with greater weight loss and with reduced mortality at Days 14 and 30 [hazard ratio (HR) 0.28, 95% confidence interval (CI): 0.15, 0.50; and 0.35, 95% CI: 0.22, 0.55, respectively]. Rolofylline administration was associated with an increase in the proportion of patients showing early dyspnoea relief (HR 1.30; 95% CI: 1.08, 1.57) and with a numerically lower mortality at 14 and 30 days, largely driven by the mortality due to HF [at 30 days, HR (95% CI, P-value): 0.65 (0.38-1.10, P = 0.107)]. Rolofylline did not reduce episodes of in-hospital worsening HF or post-discharge re-admissions, nor did it improve survival at 60 or 180 days.Conclusion The present analysis from PROTECT demonstrated that more weight loss was associated with early dyspnoea relief and reduced short-term mortality.
Databáze: OpenAIRE
Externí odkaz: