Surface modification of electrospun poly-(l-lactic) acid scaffolds by reactive magnetron sputtering
| Autor: | Yu. A. Kudryavtseva, Sergei I. Tverdokhlebov, M. V. Nasonova, E.N. Bolbasov, Yuri German Anissimov, K.S. Stankevich, A.I. Kozelskaya, E.V. Shesterikov, D. K. Shishkova, P. V. Maryin, Yu. I. Khodyrevskaya |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Poly l lactic acid
Male Reactive magnetron Scaffold Materials science Biocompatibility Plasma Gases Nitrogen Surface Properties Polyesters Subcutaneous Fat Biocompatible Materials 02 engineering and technology engineering.material 010402 general chemistry 01 natural sciences Colloid and Surface Chemistry Coating Sputtering Animals Physical and Theoretical Chemistry Fourier transform infrared spectroscopy Rats Wistar Tissue Engineering Tissue Scaffolds technology industry and agriculture Surfaces and Interfaces General Medicine Electrochemical Techniques Prostheses and Implants 021001 nanoscience & nanotechnology 0104 chemical sciences Rats Chemical engineering engineering Surface modification 0210 nano-technology Hydrophobic and Hydrophilic Interactions Biotechnology |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 162 |
| ISSN: | 1873-4367 |
| Popis: | In this study, we modified the surface of bioresorbable electrospun poly-( l -lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity. No adverse tissue reaction up to 3 months after subcutaneous implantation of the modified scaffolds was detected in in-vivo rat model. The rate of scaffold replacement by the recipient tissue in-vivo was observed to depend on the plasma treatment time. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect