Nonsense-mediated RNA decay and its bipolar function in cancer

Autor: Luísa Romão, Rafael Fernandes, Juan F. García-Moreno, Gonçalo Nogueira
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Cancer Research
Cancer therapy
Disease
Review
Environmental stress
0302 clinical medicine
Neoplasms
Tumor Microenvironment
Molecular Targeted Therapy
Tumor suppressor gene
Tumor Suppressor Gene
RC254-282
Regulation of gene expression
Genómica Funcional
Disease Management
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Combined Modality Therapy
Gene Expression Regulation
Neoplastic
Genómica Funcional e Estrutural
Cell Transformation
Neoplastic
Phenotype
Oncology
Tumor microenvironment
030220 oncology & carcinogenesis
Disease Progression
Molecular Medicine
Cancer Therapy
Disease Susceptibility
Immunotherapy
Signal Transduction
Environmental Stress
Computational biology
Biology
03 medical and health sciences
Stress
Physiological
medicine
Animals
Humans
RNA
Messenger
Oncogene
Nonsense-mediated RNA Decay (NMD)
Mechanism (biology)
Nonsense-mediated RNA decay (NMD)
Cancer
Biomarker
medicine.disease
Biomarker (cell)
Nonsense Mediated mRNA Decay
Doenças Genéticas
030104 developmental biology
Cancer cell
Neoantigen
Function (biology)
Biomarkers
Zdroj: Molecular Cancer, Vol 20, Iss 1, Pp 1-19 (2021)
Molecular Cancer
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ISSN: 1476-4598
Popis: Review Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD also degrades a significant number of normal transcripts, thus arising as a mechanism of gene expression regulation. Based on these important functions, NMD regulates several biological processes and is involved in the pathophysiology of a plethora of human genetic diseases, including cancer. The present review aims to discuss the paradoxical, pro- and anti-tumorigenic roles of NMD, and how cancer cells have exploited both functions to potentiate the disease. Considering recent genetic and bioinformatic studies, we also provide a comprehensive overview of the present knowledge of the advantages and disadvantages of different NMD modulation-based approaches in cancer therapy, reflecting on the challenges imposed by the complexity of this disease. Furthermore, we discuss significant advances in the recent years providing new perspectives on the implications of aberrant NMD-escaping frameshifted transcripts in personalized immunotherapy design and predictive biomarker optimization. A better understanding of how NMD differentially impacts tumor cells according to their own genetic identity will certainly allow for the application of novel and more effective personalized treatments in the near future. Gonçalo Nogueira, Rafael Fernandes, and Juan Fernandez García-Moreno are recipients of a fellowship from BioSys PhD programme PD65-2012 (SFRH/PD/BD/130959/2017, SFRH/BD/114392/2016 and SFRH/PD/BD/142898/2018, respectively) from FCT. This work was partially supported by UID/MULTI/04046/2019 Research Unit grant (to BioISI). info:eu-repo/semantics/publishedVersion
Databáze: OpenAIRE
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