Evidence for sympathetic neural influence on human corneal epithelial function
| Autor: | Timo Tervo, Brien A. Holden, Deborah F. Sweeney, Antti Vannas, Timo Telaranta |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Sympathetic nervous system medicine.medical_specialty Horner Syndrome Sympathetic Nervous System genetic structures Stellate Ganglion Corneal Touch Epithelium Cornea 03 medical and health sciences Oxygen Consumption 0302 clinical medicine Ophthalmology medicine Humans Aged Corneal epithelium Resting state fMRI business.industry General Medicine Anatomy Middle Aged eye diseases medicine.anatomical_structure Oxygen uptake rate 030221 ophthalmology & optometry Female Sympathetic innervation sense organs Neuron business 030217 neurology & neurosurgery Autonomic Nerve Block |
| Zdroj: | Acta Ophthalmologica. 63:215-220 |
| ISSN: | 1755-375X |
| DOI: | 10.1111/j.1755-3768.1985.tb01536.x |
| Popis: | Patients with unilateral Horner's syndrome were studied to determine the influence of sympathetic innervation on the structure and function of the human cornea. There was no difference in total corneal thickness, corneal oxygen uptake rate or corneal touch threshold between the normal and Horner's eyes of these patients. Epithelial thickness, however, was slightly but significantly greater in the Horner's eye than in the normal fellow eye (P less than 0.025). When subjected to a hypoxic "Stress Test", patients with post-ganglionic lesions showed significantly more epithelial greying and microcystic oedema (P less than 0.025 and P less than 0.01, respectively) and reported seeing smaller and brighter haloes in the Horner's eye. The cornea of the affected eye of these patients also showed a significantly shower rate of deswelling in the first hour following the "Stress Test" (P less than 0.05). These findings suggest that both in the resting state and when the cornea is physiologically challenged, the sympathetic nervous system and in particular, the terminal sympathetic neuron, has a small but significant influence on the human corneal epithelium. |
| Databáze: | OpenAIRE |
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