Cerebrospinal Fluid Tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the Relationship between Repetitive Head Impacts, Microglial Activation, and Neurodegeneration
| Autor: | Michael L. Alosco, Kaj Blennow, Henrik Zetterberg, Ann C. McKee, Shannon Conneely, Robert S. Stern, Nathan G. Fritts, Robert C. Cantu, Amanda Heslegrave, Thor D. Stein, Jesse Mez, Leslie M. Shaw, Melissa Mariani, John Q. Trojanowski, Christine M. Baugh, Samuel Frank, Brett M. Martin, Yorghos Tripodis |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Amyloid β Epidemiology Football tau Proteins Article Chronic Traumatic Encephalopathy 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cerebrospinal fluid Developmental Neuroscience Internal medicine mental disorders Concussion medicine Humans Receptors Immunologic Amyloid beta-Peptides Membrane Glycoproteins medicine.diagnostic_test Lumbar puncture business.industry Health Policy Neurodegeneration Middle Aged medicine.disease Psychiatry and Mental health Chronic traumatic encephalopathy 030104 developmental biology Endocrinology Tau phosphorylation Nerve Degeneration Neurology (clinical) Microglia Geriatrics and Gerontology business 030217 neurology & neurosurgery Biomarkers |
| Popis: | Introduction Cerebrospinal fluid (CSF) protein analysis may facilitate detection and elucidate mechanisms of neurological consequences from repetitive head impacts (RHI), such as chronic traumatic encephalopathy. We examined CSF concentrations of total tau (t-tau), phosphorylated tau, and amyloid β 1-42 and their association with RHI in former National Football League (NFL) players. The role of microglial activation (using sTREM2) was examined as a pathogenic mechanism of chronic traumatic encephalopathy. Methods Sixty-eight former NFL players and 21 controls underwent lumbar puncture to quantify t-tau, p-tau 181 , amyloid β 1-42 , and sTREM2 in the CSF using immunoassays. The cumulative head impact index estimated RHI. Results No between-group differences for CSF analytes emerged. In the former NFL players, the cumulative head impact index predicted higher t-tau concentrations ( P = .041), and higher sTREM2 levels were associated with higher t-tau concentrations ( P = .009). Discussion In this sample of former NFL players, greater RHI and increased microglial activation were associated with higher CSF t-tau concentrations. |
| Databáze: | OpenAIRE |
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