The effects of acute and chronic haloperidol treatment on spontaneously firing neurons in the caudate nucleus of the rat
| Autor: | L.R. Skirboll, Benjamin S. Bunney |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
Time Factors Dopamine Caudate nucleus Motor Activity Pharmacology Inhibitory postsynaptic potential Tardive dyskinesia General Biochemistry Genetics and Molecular Biology Pathogenesis Postsynaptic potential medicine Haloperidol Animals General Pharmacology Toxicology and Pharmaceutics Neurons Behavior Animal Iontophoresis business.industry Body Weight General Medicine medicine.disease Rats Electrophysiology Anesthesia Caudate Nucleus business medicine.drug |
| Zdroj: | Life Sciences. 25:1419-1433 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(79)90420-x |
| Popis: | Two types of spontaneous activity were found in the caudate nucleus of the rat: Type I and Type II. The effects of haloperidol (HAL) on firing rate and number of spontaneously active Type I and Type II units was tested after three different treatment regimens-- a single dose, 22 daily doses and 1 week after 22 days of treatment. The responses of the two types of units were found to differ from each other in each treatment group. Supersensitive responses to iontophoretic dopamine (DA) were found in Type I units both during chronic HAL treatment and 1 week after drug termination. However, parenteral or subcutaneous HAL administered acutely or chronically, failed to block the inhibitory effects of iontophoretic DA on these neurons. Our findings provide further support for the development of DA postsynaptic supersensitivity being involved in the pathogenesis of tardive dyskinesia, but raise questions concerning the mechanism by which HAL induces this effect. |
| Databáze: | OpenAIRE |
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