Predicting the response of the dental pulp to SARS-CoV2 infection: a transcriptome-wide effect cross-analysis

Autor: Pietro Hiram Guzzi, Federico M. Giorgi, Johnah C. Galicia, Asma A. Khan
Přispěvatelé: Galicia J.C., Guzzi P.H., Giorgi F.M., Khan A.A.
Rok vydání: 2020
Předmět:
0301 basic medicine
Datasets as Topic
Disease
Pathogenesis
Transcriptome
0302 clinical medicine
Receptors
Viru
Genetics(clinical)
Pulpitis
skin and connective tissue diseases
Genetics (clinical)
Regulation of gene expression
Serine Endopeptidases
Receptors
Virus
Angiotensin-Converting Enzyme 2
medicine.symptom
Coronavirus Infections
Infection
Pulpiti
Human
Pneumonia
Viral
Immunology
Inflammation
Peptidyl-Dipeptidase A
Biology
Brief Communication
Betacoronavirus
03 medical and health sciences
stomatognathic system
Human interactome
Genetics
medicine
Humans
Pandemics
Dental Pulp
Betacoronaviru
Pandemic
Coronavirus Infection
SARS-CoV-2
Gene Expression Profiling
COVID-19
Receptors
Coronaviru
medicine.disease
Gene expression profiling
stomatognathic diseases
030104 developmental biology
Gene Expression Regulation
Gene expression
Receptors
Coronavirus
030215 immunology
Zdroj: Genes and Immunity
Genes & Immunity
ISSN: 1476-5470
1466-4879
Popis: Pulpitis, inflammation of the dental pulp, is a disease that often necessitates emergency dental care. While pulpitis is considered to be a microbial disease primarily caused by bacteria, viruses have also been implicated in its pathogenesis. Here, we determined the expression of the SARS-CoV2 receptor, angiotensin converting enzyme 2 (ACE2) and its associated cellular serine protease TPMRSS2 in the dental pulp under normal and inflamed conditions. Next, we explored the relationship between the SARS-CoV-2/human interactome and genes expressed in pulpitis. Using existing datasets we show that both ACE2 and TPMRSS2 are expressed in the dental pulp and, that their expression does not change under conditions of inflammation. Furthermore, Master Regulator Analysis of the SARS-CoV2/human interactome identified 75 relevant genes whose expression values are either up-regulated or down-regulated in both the human interactome and pulpitis. Our results suggest that the dental pulp is vulnerable to SARS-CoV2 infection and that SARS-CoV-2 infection of the dental pulp may contribute to worse outcomes of pulpitis.
Databáze: OpenAIRE
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