Predicting the response of the dental pulp to SARS-CoV2 infection: a transcriptome-wide effect cross-analysis
Autor: | Pietro Hiram Guzzi, Federico M. Giorgi, Johnah C. Galicia, Asma A. Khan |
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Přispěvatelé: | Galicia J.C., Guzzi P.H., Giorgi F.M., Khan A.A. |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Datasets as Topic Disease Pathogenesis Transcriptome 0302 clinical medicine Receptors Viru Genetics(clinical) Pulpitis skin and connective tissue diseases Genetics (clinical) Regulation of gene expression Serine Endopeptidases Receptors Virus Angiotensin-Converting Enzyme 2 medicine.symptom Coronavirus Infections Infection Pulpiti Human Pneumonia Viral Immunology Inflammation Peptidyl-Dipeptidase A Biology Brief Communication Betacoronavirus 03 medical and health sciences stomatognathic system Human interactome Genetics medicine Humans Pandemics Dental Pulp Betacoronaviru Pandemic Coronavirus Infection SARS-CoV-2 Gene Expression Profiling COVID-19 Receptors Coronaviru medicine.disease Gene expression profiling stomatognathic diseases 030104 developmental biology Gene Expression Regulation Gene expression Receptors Coronavirus 030215 immunology |
Zdroj: | Genes and Immunity Genes & Immunity |
ISSN: | 1476-5470 1466-4879 |
Popis: | Pulpitis, inflammation of the dental pulp, is a disease that often necessitates emergency dental care. While pulpitis is considered to be a microbial disease primarily caused by bacteria, viruses have also been implicated in its pathogenesis. Here, we determined the expression of the SARS-CoV2 receptor, angiotensin converting enzyme 2 (ACE2) and its associated cellular serine protease TPMRSS2 in the dental pulp under normal and inflamed conditions. Next, we explored the relationship between the SARS-CoV-2/human interactome and genes expressed in pulpitis. Using existing datasets we show that both ACE2 and TPMRSS2 are expressed in the dental pulp and, that their expression does not change under conditions of inflammation. Furthermore, Master Regulator Analysis of the SARS-CoV2/human interactome identified 75 relevant genes whose expression values are either up-regulated or down-regulated in both the human interactome and pulpitis. Our results suggest that the dental pulp is vulnerable to SARS-CoV2 infection and that SARS-CoV-2 infection of the dental pulp may contribute to worse outcomes of pulpitis. |
Databáze: | OpenAIRE |
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