Age‐adjusted reference values for prostate‐specific antigen in a multi‐ethnic population
| Autor: | Bashar Matti, Kamran Zargar-Shoshtari |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Percentile Urology Age adjustment Population 030232 urology & nephrology Ethnic group 03 medical and health sciences Prostate cancer 0302 clinical medicine Antigen Reference Values Ethnicity Humans Medicine education Aged education.field_of_study business.industry Age Factors Prostatic Neoplasms Middle Aged Prostate-Specific Antigen medicine.disease Prostate-specific antigen 030220 oncology & carcinogenesis Cohort business Demography |
| Zdroj: | International Journal of Urology. 28:578-583 |
| ISSN: | 1442-2042 0919-8172 |
| DOI: | 10.1111/iju.14519 |
| Popis: | OBJECTIVE To establish age-adjusted reference values for prostate-specific antigen in an ethnically diverse population. METHODS Between 2009 and 2017, data were collected from all men aged 40-79 years, who had a prostate-specific antigen test in the northern region of New Zealand, where the prostate-specific antigen testing service is provided by a single community laboratory and using the same assay analyzer. Men known to have prostate cancer, who developed prostate cancer during the study period, who were treated with finasteride, or who had prostate-specific antigen levels above 20 ng/mL were excluded. Age-adjusted prostate-specific antigen reference values were calculated for each of the main ethnic groups in the country including: Māori (indigenous), Pacific, Asian and European. For every 5-year age interval, the 95th percentile of the log prostate-specific antigen distribution was used to define the upper limit of normal. RESULTS The study cohort included 215 132 apparently healthy men, with a median age and prostate-specific antigen concentration of 59 years and 0.9 ng/mL, respectively. Prostate-specific antigen levels for the entire cohort increased with age (Pearson correlation = 0.362, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|