Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types
| Autor: | Mary Carrington, Michie Hisada, James J. Goedert, Owen St. C. Morgan, Nilanjan Chatterjee, Hongchuan Li, Norma Kim, Beverley Cranston, Xiao Jiang Gao, Barrie Hanchard, Shunro Sonoda, Robert J. Biggar |
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| Rok vydání: | 2007 |
| Předmět: |
Cancer Research
Cellular immunity Jamaica viruses Human leukocyte antigen Human T-lymphotropic virus Asymptomatic immune system diseases HLA Antigens Risk Factors hemic and lymphatic diseases Tropical spastic paraparesis Prevalence Medicine Humans Risk factor Alleles biology business.industry virus diseases Odds ratio medicine.disease biology.organism_classification HTLV-I Infections Oncology Immunology medicine.symptom business Asymptomatic carrier |
| Zdroj: | International journal of cancer. 121(5) |
| ISSN: | 0020-7136 |
| Popis: | Human T-lymphotropic virus-I (HTLV-I) causes adult T-cell leukemia/lymphoma (ATL) and HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We postulated a higher disease risk for people with common human leukocyte antigen (HLA) types, due to a narrower immune response against viral or neoplastic antigens, compared to people with uncommon types. HLA class-I (A,B) and class-II (DRB1, DQB1) allele and haplotype frequencies in 56 ATL patients, 59 HAM/TSP patients and 190 population-based, asymptomatic HTLV-I-infected carriers were compared by logistic regression overall (score test) and with odds ratios (ORs) for common types (prevalence >50% of asymptomatic carriers) and by prevalence quartile. HTLV-I proviral load between asymptomatic carriers with common versus uncommon types was compared by t-test. ATL differed from asymptomatic carriers in overall DQB1 allele and class-I haplotype frequencies (p ≤≤ 0.04). ATL risk was increased significantly with common HLA-B (OR 2.25, 95% CI 1.19–4.25) and DRB1 (OR 2.11, 95% CI 1.13–3.40) alleles. Higher prevalence HLA-B alleles were associated with higher ATL risk (OR 1.14 per quartile, ptrend = 0.02). Asymptomatic carriers with common HLA-B alleles had marginally higher HTLV-I proviral load (p = 0.057). HAM/TSP risk did not differ consistently with common HLA types. Thus, ATL risk, but not HAM/TSP risk, was increased with higher prevalence HLA-B alleles. Perhaps breadth of cellular immunity affects risk of this viral leukemia/lymphoma. © 2007 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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