Changes in Brain Energy and Membrane Metabolism in Glioblastoma following Chemoradiation
| Autor: | Julian Mangesius, Ivan Radovic, Malik Galijašević, Christian F. Freyschlag, Johannes Kerschbaumer, Lisa Maria Walchhofer, Elke R. Gizewski, Astrid E. Grams, Andreas Rietzler, Stephanie Mangesius, Martha Nowosielski, Ruth Steiger |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
In vivo magnetic resonance spectroscopy Pathology medicine.medical_specialty Magnetic Resonance Spectroscopy Imaging biomarker Metabolite cerebral energy metabolism phosphorous magnetic resonance spectroscopy (31P-MRS) ATP glioblastoma chemoradiation normal-appearing brain tissue tumor infiltration Article chemistry.chemical_compound Parenchyma medicine Humans RC254-282 medicine.diagnostic_test business.industry Brain Neoplasms. Tumors. Oncology. Including cancer and carcinogens Magnetic resonance imaging Chemoradiotherapy Metabolism medicine.disease Magnetic Resonance Imaging chemistry Female business Progressive disease Glioblastoma |
| Zdroj: | Current Oncology; Volume 28; Issue 6; Pages: 5041-5053 Current Oncology, Vol 28, Iss 424, Pp 5041-5053 (2021) Current Oncology |
| ISSN: | 1718-7729 |
| DOI: | 10.3390/curroncol28060424 |
| Popis: | Brain parenchyma infiltration with glioblastoma (GB) cannot be entirely visualized by conventional magnetic resonance imaging (MRI). The aim of this study was to investigate changes in the energy and membrane metabolism measured with phosphorous MR spectroscopy (31P-MRS) in the presumably “normal-appearing” brain following chemoradiation therapy (CRT) in GB patients in comparison to healthy controls. Twenty (seven female, thirteen male) GB patients underwent a 31P-MRS scan prior to surgery (baseline) and after three months of standard CRT (follow-up examination. The regions of interest “contrast-enhancing (CE) tumor” (if present), “adjacent to the (former) tumor”, “ipsilateral distant” hemisphere, and “contralateral” hemisphere were compared, differentiating between patients with stable (SD) and progressive disease (PD). Metabolite ratios PCr/ATP, Pi/ATP, PCr/Pi, PME/PDE, PME/PCr, and PDE/ATP were investigated. In PD, energy and membrane metabolism in CE tumor areas have a tendency to “normalize” under therapy. In different “normal-appearing” brain areas of GB patients, the energy and membrane metabolism either “normalized” or were “disturbed”, in comparison to baseline or controls. Differences were also detected between patients with SD and PD. 31P-MRS might contribute as an additional imaging biomarker for outcome measurement, which remains to be investigated in a larger cohort. |
| Databáze: | OpenAIRE |
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