Human Parvovirus 4: A harmless bystander or a pathogen of severe acute respiratory illness
| Autor: | Vangala Ramakrishna, Hricha Mishra, Amita Jain, Shantanu Prakash, Suruchi Shukla, Amit Bhagat |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) Adolescent Genotype 030106 microbiology India Human parvovirus Nose Real-Time Polymerase Chain Reaction Article PARVO 4 virus Virus lcsh:Infectious and parasitic diseases Parvoviridae Infections Parvovirus Young Adult 03 medical and health sciences 0302 clinical medicine Bystander effect Humans Medicine lcsh:RC109-216 030212 general & internal medicine Respiratory system Child Respiratory Tract Infections Pathogen Respiratory illness business.industry Case-control study Infant General Medicine Middle Aged Infectious Diseases Case-Control Studies Child Preschool DNA Viral Immunology Severe acute respiratory illness Pharynx Female business |
| Zdroj: | International Journal of Infectious Diseases International Journal of Infectious Diseases, Vol 90, Iss, Pp 21-25 (2020) |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2019.10.001 |
| Popis: | Highlights • Severe Acute Respiratory Infection (SARI) is an important cause of morbidity and mortality worldwide. • We investigated the association of PARV4 virus with SARI. • PARV4 was detected in 26.55% of cases and only in one healthy control (0.68%). • Detection of PARV4 is seen in a significantly large number of SARI cases. • PARV4 genotype 2 was the only genotype detected from cases as well as controls. Introduction Severe Acute Respiratory Infection (SARI) is an important cause of morbidity and mortality worldwide, caused by a large number of viral and bacterial agents. PARV4 is a recently identified virus detected in human blood and variety of tissues, but its disease association with SARI could not be established. Objective In the present case control study, we aim to investigate the association of PARV4 with SARI. Methods The Nasal and Throat swab (NS/TS) samples of 241 cases and 146 healthy controls were tested for most common respiratory viruses and PARV4 by real-time PCR. Results PARV4 was detected in 64(26.55%) SARI cases and only one healthy control (0.68%). PARV4 was the most common viral agent detected in SARI cases. A strong association of PARV4 is seen with severe respiratory illness. Conclusion Detection of PARV4 in a significantly higher number of SARI cases, in comparison with controls, suggests association of PARV4 with SARI. PARV4 genotype 2 is the only circulating strain detected in our study. |
| Databáze: | OpenAIRE |
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